The cytotoxic effect of newly synthesized ferrocenes against
cervical carcinoma cells and their combination with
radiotherapy

k 2018

The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy

SKOUPILOVÁ, Hana; Vladimír RAK; Jindřich KARBAN; Jiří PINKAS; Martin BARTOŠÍK et al.

Základní údaje

Originální název

The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy

Název česky

Cytotoxický efekt nově syntetizovaných ferrocenů na buněčných liniích cervikálního karcinomu a jejich kombinace s radioterapií

Název anglicky

The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy

Autoři

SKOUPILOVÁ, Hana; Vladimír RAK; Jindřich KARBAN; Jiří PINKAS; Martin BARTOŠÍK a Roman HRSTKA

Vydání

XIX. Meeting of Biochemists and Molecular Biologists. 2018

Další údaje

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Změněno: 22. 8. 2019 12:28, Mgr. Hana Kubušová, Ph.D.

Anotace

V originále

Cervical carcinoma is the fourth most common cancer diagnosed in women worldwide. The widespread use of cervical screening programs along with vaccination against the most common HPVs has significantly reduced rates of cervical carcinoma. Despite that, it was estimated that cervical cancer is newly diagnosed in more than half a million women worldwide annually and causes approximately quarter of the million deaths (1). Surgery is commonly used as the first option for patients with early stage cancers. In advanced tumors, curative radiotherapy combined with platinum based chemotherapy represents the treatment of choice. This combination improves local control and overall survival (2, 3). Although cisplatin along with other platinum substances are widely used, they also show significant limiting properties such as development of resistance and serious negative side effects such as nephrotoxicity and neurotoxicity. For this reason, we focused on development of new organometallic compounds, which would replace highly toxic platinum derivatives. In our research a panel of new ferrocene based compounds (4, 5) which carry saturated nitrogen-containing five- and six-membered nitrogen-containing heterocycles was synthesized and tested on cytotoxicity towards cell lines derived from cervical carcinomas. The cytotoxic substances selected by this way were further tested in combination with irradiation in order to imitate standard treatment. Clear changes in the cell cycle and cell signaling pathways were observed after combined treatment indicating promising antitumor activity of several studied substances in combination with radiotherapy. Further examination of selected compounds and their synergistic action with ionizing radiation may result in clinically useful treatment combinations.

Citovat

SKOUPILOVÁ, Hana; Vladimír RAK; Jindřich KARBAN; Jiří PINKAS; Martin BARTOŠÍK a Roman HRSTKA. The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy. In XIX. Meeting of Biochemists and Molecular Biologists. 2018.

@proceedings{1550117,
   author = {Skoupilová, Hana and Rak, Vladimír and Karban, Jindřich and Pinkas, Jiří and Bartošík, Martin and Hrstka, Roman},
   booktitle = {XIX. Meeting of Biochemists and Molecular Biologists.},
   title = {The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy},
   year = {2018}
}

TY  - CONF
ID  - 1550117
AU  - Skoupilová, Hana - Rak, Vladimír - Karban, Jindřich - Pinkas, Jiří - Bartošík, Martin - Hrstka, Roman
PY  - 2018
TI  - The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy
N2  - Cervical carcinoma is the fourth most common cancer diagnosed in women worldwide. The widespread use of cervical screening programs along with vaccination against the most common HPVs has significantly reduced rates of cervical carcinoma. Despite that, it was estimated that cervical cancer is newly diagnosed in more than half a million women worldwide annually and causes approximately quarter of the million deaths (1). Surgery is commonly used as the first option for patients with early stage cancers. In advanced tumors, curative radiotherapy combined with platinum based chemotherapy represents the treatment of choice. This combination improves local control and overall survival (2, 3). Although cisplatin along with other platinum substances are widely used, they also show significant limiting properties such as development of resistance and serious negative side effects such as nephrotoxicity and neurotoxicity. For this reason, we focused on development of new organometallic compounds, which would replace highly toxic platinum derivatives. In our research a panel of new ferrocene based compounds (4, 5) which carry saturated nitrogen-containing five- and six-membered nitrogen-containing heterocycles was synthesized and tested on cytotoxicity towards cell lines derived from cervical carcinomas. The cytotoxic substances selected by this way were further tested in combination with irradiation in order to imitate standard treatment. Clear changes in the cell cycle and cell signaling pathways were observed after combined treatment indicating promising antitumor activity of several studied substances in combination with radiotherapy. Further examination of selected compounds and their synergistic action with ionizing radiation may result in clinically useful treatment combinations.
ER  -

SKOUPILOVÁ, Hana; Vladimír RAK; Jindřich KARBAN; Jiří PINKAS; Martin BARTOŠÍK a Roman HRSTKA. The cytotoxic effect of newly synthesized ferrocenes against cervical carcinoma cells and their combination with radiotherapy. In \textit{XIX. Meeting of Biochemists and Molecular Biologists.}. 2018.

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