The cytotoxic effect of ferrocene derivatives in combination with radiotherapy against cervical carcinoma cells

SKOUPILOVÁ, Hana; Vladimír RAK; Jindřich KARBAN; Jiří PINKAS a Roman HRSTKA. The cytotoxic effect of ferrocene derivatives in combination with radiotherapy against cervical carcinoma cells. In Chemistry and biology of phytohormones and related substances. 2019.

Základní údaje

Originální název

The cytotoxic effect of ferrocene derivatives in combination with radiotherapy against cervical carcinoma cells

Název česky

Cytotoxický účinek derivátů ferocenu v kombinaci s radioterapií v buněčných liniích karcinomu děložního čípku

Autoři

SKOUPILOVÁ, Hana; Vladimír RAK; Jindřich KARBAN; Jiří PINKAS a Roman HRSTKA

Vydání

Chemistry and biology of phytohormones and related substances, 2019

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Další údaje

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ne

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Anotace

V originále

Cervical cancer is the the second most frequent female malignancy. Despite the availability of preventive screening program and vaccination against most prevalent „high-risk“ human papillomaviruses (HPV), approximately 400 women die due to cervical cancer each year in the Czech Republic. Optimal treatment choice depends on the stage of the disease. Early stages are treated by surgery. More advanced stages are usually treated with a combination of radiotherapy and chemotherapy. Most commonly used chemotherapeutic drug is still cisplatin, which has a good antitumor effect but also serious toxicity. This fact led us to the synthesis and testing of new potential anti-cancer organometallic compounds. A series of new structures based on ferrocene moiety was tested in vitro and showed even better efficiency than cisplatin.