Mixed copper(ii)-phenanthroline complexes induce cell death of
ovarian cancer cells by evoking the unfolded protein response

J 2019

Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response

MORÁŇ, Lukáš; Tiziana PIVETTA; Sebastiano MASURI; Kateřina VAŠÍČKOVÁ; Franziska WALTER et. al.

Základní údaje

Originální název

Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response

Autoři

MORÁŇ, Lukáš; Tiziana PIVETTA; Sebastiano MASURI; Kateřina VAŠÍČKOVÁ; Franziska WALTER; Jochen PREHN; Moustafa ELKALAF; Jan TRNKA; Josef HAVEL a Petr VAŇHARA

Vydání

Metallomics, Cambridge, ROYAL SOC CHEMISTRY, 2019, 1756-5901

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.796

Kód RIV

RIV/00216224:14110/19:00110493

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1039/c9mt00055k

UT WoS

000487053000003

EID Scopus

2-s2.0-85071628759

Klíčová slova anglicky

ENDOPLASMIC-RETICULUM STRESS; LIGAND COPPER(II) COMPLEXES; DNA CLEAVAGE; TUMOR-CELLS; CISPLATIN; 1_10-PHENANTHROLINE; PHENANTHROLINE; APOPTOSIS; BINDING; CYTOTOXICITY

Štítky

14110517, CF CELLIM, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 2. 2025 14:05, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

There is an ongoing need for the development of new cancer therapeutics that combine high cytotoxic efficiency with low side effects, and also override resistance to the first-line chemotherapeutics. Copper(II)–phenanthroline complexes are promising compounds that were shown previously to induce an immediate cytotoxic response over a panel of tumor cell lines in vitro. The molecular mechanism, however, remained unresolved. In this work we performed a thorough study of the copper(II)–phenanthroline complexes containing different imidazolidine-2-thione ligands in ovarian cancer cells, and revealed that these complexes induce endoplasmic reticulum (ER) stress and subsequently cell death mediated by the unfolded protein response. Alleviation of the ER-stress by tauroursodeoxycholic acid (TUDCA) attenuated the cytotoxic effects. In summary, we have identified a novel, ER-dependent, molecular mechanism mediating cytotoxic effects of copper(II)–phenanthroline complexes.

Návaznosti

EE2.3.20.0185, projekt VaV

Název: Centrum analýz a modelování tkání a orgánů

MUNI/A/1565/2018, interní kód MU

Název: Zdroje pro tkáňové inženýrství 9 (Akronym: TissueEng 9)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 9, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

Citovat

MORÁŇ, Lukáš; Tiziana PIVETTA; Sebastiano MASURI; Kateřina VAŠÍČKOVÁ; Franziska WALTER; Jochen PREHN; Moustafa ELKALAF; Jan TRNKA; Josef HAVEL a Petr VAŇHARA. Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response. Metallomics. Cambridge: ROYAL SOC CHEMISTRY, 2019, roč. 11, č. 9, s. 1481-1489. ISSN 1756-5901. Dostupné z: https://doi.org/10.1039/c9mt00055k.

@article{1550502,
   author = {Moráň, Lukáš and Pivetta, Tiziana and Masuri, Sebastiano and Vašíčková, Kateřina and Walter, Franziska and Prehn, Jochen and Elkalaf, Moustafa and Trnka, Jan and Havel, Josef and Vaňhara, Petr},
   article_location = {Cambridge},
   article_number = {9},
   doi = {https://doi.org/10.1039/c9mt00055k},
   keywords = {ENDOPLASMIC-RETICULUM STRESS; LIGAND COPPER(II) COMPLEXES; DNA CLEAVAGE; TUMOR-CELLS; CISPLATIN; 1_10-PHENANTHROLINE; PHENANTHROLINE; APOPTOSIS; BINDING; CYTOTOXICITY},
   language = {eng},
   issn = {1756-5901},
   journal = {Metallomics},
   title = {Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response},
   url = {http://dx.doi.org/10.1039/c9mt00055k},
   volume = {11},
   year = {2019}
}

TY  - JOUR
ID  - 1550502
AU  - Moráň, Lukáš - Pivetta, Tiziana - Masuri, Sebastiano - Vašíčková, Kateřina - Walter, Franziska - Prehn, Jochen - Elkalaf, Moustafa - Trnka, Jan - Havel, Josef - Vaňhara, Petr
PY  - 2019
TI  - Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response
JF  - Metallomics
VL  - 11
IS  - 9
SP  - 1481-1489
EP  - 1481-1489
PB  - ROYAL SOC CHEMISTRY
SN  - 17565901
KW  - ENDOPLASMIC-RETICULUM STRESS
KW  - LIGAND COPPER(II) COMPLEXES
KW  - DNA CLEAVAGE
KW  - TUMOR-CELLS
KW  - CISPLATIN
KW  - 1_10-PHENANTHROLINE
KW  - PHENANTHROLINE
KW  - APOPTOSIS
KW  - BINDING
KW  - CYTOTOXICITY
UR  - http://dx.doi.org/10.1039/c9mt00055k
L2  - http://dx.doi.org/10.1039/c9mt00055k
N2  - There is an ongoing need for the development of new cancer therapeutics that combine high cytotoxic efficiency with low side effects, and also override resistance to the first-line chemotherapeutics. Copper(II)–phenanthroline complexes are promising compounds that were shown previously to induce an immediate cytotoxic response over a panel of tumor cell lines in vitro. The molecular mechanism, however, remained unresolved. In this work we performed a thorough study of the copper(II)–phenanthroline complexes containing different imidazolidine-2-thione ligands in ovarian cancer cells, and revealed that these complexes induce endoplasmic reticulum (ER) stress and subsequently cell death mediated by the unfolded protein response. Alleviation of the ER-stress by tauroursodeoxycholic acid (TUDCA) attenuated the cytotoxic effects. In summary, we have identified a novel, ER-dependent, molecular mechanism mediating cytotoxic effects of copper(II)–phenanthroline complexes.
ER  -

MORÁŇ, Lukáš; Tiziana PIVETTA; Sebastiano MASURI; Kateřina VAŠÍČKOVÁ; Franziska WALTER; Jochen PREHN; Moustafa ELKALAF; Jan TRNKA; Josef HAVEL a Petr VAŇHARA. Mixed copper(ii)-phenanthroline complexes induce cell death of ovarian cancer cells by evoking the unfolded protein response. \textit{Metallomics}. Cambridge: ROYAL SOC CHEMISTRY, 2019, roč.~11, č.~9, s.~1481-1489. ISSN~1756-5901. Dostupné z: https://doi.org/10.1039/c9mt00055k.

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