Determinants of CAT (COPD Assessment Test) scores in a
population of patients with COPD in central and Eastern Europe:
The POPE study

J 2019

Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study

MIRAVITLLES, Marc; Vladimir KOBLIZEK; Cristina ESQUINAS; Branislava MILENKOVIC; Adam BARCZYK et al.

Základní údaje

Originální název

Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study

Autoři

Vydání

RESPIRATORY MEDICINE, LONDON, W B SAUNDERS CO LTD, 2019, 0954-6111

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.095

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/19:00110576

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

COPD; CAT; mMRC; Comorbidities; GOLD classification

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 9. 2019 15:03, Mgr. Tereza Miškechová

Anotace

V originále

Background: The COPD Assessment Test (CAT) has been proposed to help guide therapy in chronic obstructive pulmonary disease (COPD). It is important to understand the distribution of scores in different COPD populations and their determinants. Methods: The POPE study is an international, observational cross-sectional study of COPD subjects in 11 Central and Eastern European countries aimed at characterizing COPD phenotypes. Here we report the analysis of CAT scores with the objective of identifying their determinants, evaluating symptom load and investigating the distribution of scores among the participating countries. Additionally, we investigated the discrepancies between the CAT and modified Medical Research Council (mMRC) scores when used to classify patients according to the GOLD strategy. Results: The study included 3452 patients (69.2% men, mean forced expiratory volume in 1 s (FEV1% predicted) 52.5%). The mean CAT score was 17.5 (SD = 7.8), ranging from 15.1 in Hungary to 21.2 in Bulgaria. Multiple linear regression analysis showed six variables significantly associated with CAT scores: depression, number of previous exacerbations, 6-min walking distance, FEV1(%), mMRC and country and explained 47.2% of the variance of CAT. According to either CAT or mMRC, up to 23.9% patients would be classified in different GOLD groups. Conclusions: The CAT score may be predicted by factors related to COPD severity, depression and exercise capacity, with significant differences in the distribution of CAT scores in different countries. According to our results CAT > 10 is not equivalent to mMRC > 2 for assessing symptom burden.

Citovat

MIRAVITLLES, Marc; Vladimir KOBLIZEK; Cristina ESQUINAS; Branislava MILENKOVIC; Adam BARCZYK; Ruzena TKACOVA; Attila SOMFAY; Kirill ZYKOV; Neven TUDORIC; Kosta KOSTOV; Zuzana ZBOŽÍNKOVÁ; Michal SVOBODA; Jurij SORLI; Alvils KRAMS a Arschang VALIPOUR. Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study. RESPIRATORY MEDICINE. LONDON: W B SAUNDERS CO LTD, 2019, roč. 150, APR 2019, s. 141-148. ISSN 0954-6111. Dostupné z: https://doi.org/10.1016/j.rmed.2019.03.007.

@article{1552417,
   author = {Miravitlles, Marc and Koblizek, Vladimir and Esquinas, Cristina and Milenkovic, Branislava and Barczyk, Adam and Tkacova, Ruzena and Somfay, Attila and Zykov, Kirill and Tudoric, Neven and Kostov, Kosta and Zbožínková, Zuzana and Svoboda, Michal and Sorli, Jurij and Krams, Alvils and Valipour, Arschang},
   article_location = {LONDON},
   article_number = {APR 2019},
   doi = {https://doi.org/10.1016/j.rmed.2019.03.007},
   keywords = {COPD; CAT; mMRC; Comorbidities; GOLD classification},
   language = {eng},
   issn = {0954-6111},
   journal = {RESPIRATORY MEDICINE},
   title = {Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study},
   url = {http://dx.doi.org/10.1016/j.rmed.2019.03.007},
   volume = {150},
   year = {2019}
}

TY  - JOUR
ID  - 1552417
AU  - Miravitlles, Marc - Koblizek, Vladimir - Esquinas, Cristina - Milenkovic, Branislava - Barczyk, Adam - Tkacova, Ruzena - Somfay, Attila - Zykov, Kirill - Tudoric, Neven - Kostov, Kosta - Zbožínková, Zuzana - Svoboda, Michal - Sorli, Jurij - Krams, Alvils - Valipour, Arschang
PY  - 2019
TI  - Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study
JF  - RESPIRATORY MEDICINE
VL  - 150
IS  - APR 2019
SP  - 141-148
EP  - 141-148
PB  - W B SAUNDERS CO LTD
SN  - 09546111
KW  - COPD
KW  - CAT
KW  - mMRC
KW  - Comorbidities
KW  - GOLD classification
UR  - http://dx.doi.org/10.1016/j.rmed.2019.03.007
L2  - http://dx.doi.org/10.1016/j.rmed.2019.03.007
N2  - Background: The COPD Assessment Test (CAT) has been proposed to help guide therapy in chronic obstructive pulmonary disease (COPD). It is important to understand the distribution of scores in different COPD populations and their determinants. Methods: The POPE study is an international, observational cross-sectional study of COPD subjects in 11 Central and Eastern European countries aimed at characterizing COPD phenotypes. Here we report the analysis of CAT scores with the objective of identifying their determinants, evaluating symptom load and investigating the distribution of scores among the participating countries. Additionally, we investigated the discrepancies between the CAT and modified Medical Research Council (mMRC) scores when used to classify patients according to the GOLD strategy. Results: The study included 3452 patients (69.2% men, mean forced expiratory volume in 1 s (FEV1% predicted) 52.5%). The mean CAT score was 17.5 (SD = 7.8), ranging from 15.1 in Hungary to 21.2 in Bulgaria. Multiple linear regression analysis showed six variables significantly associated with CAT scores: depression, number of previous exacerbations, 6-min walking distance, FEV1(%), mMRC and country and explained 47.2% of the variance of CAT. According to either CAT or mMRC, up to 23.9% patients would be classified in different GOLD groups. Conclusions: The CAT score may be predicted by factors related to COPD severity, depression and exercise capacity, with significant differences in the distribution of CAT scores in different countries. According to our results CAT > 10 is not equivalent to mMRC > 2 for assessing symptom burden.
ER  -

MIRAVITLLES, Marc; Vladimir KOBLIZEK; Cristina ESQUINAS; Branislava MILENKOVIC; Adam BARCZYK; Ruzena TKACOVA; Attila SOMFAY; Kirill ZYKOV; Neven TUDORIC; Kosta KOSTOV; Zuzana ZBOŽÍNKOVÁ; Michal SVOBODA; Jurij SORLI; Alvils KRAMS a Arschang VALIPOUR. Determinants of CAT (COPD Assessment Test) scores in a population of patients with COPD in central and Eastern Europe: The POPE study. \textit{RESPIRATORY MEDICINE}. LONDON: W B SAUNDERS CO LTD, 2019, roč.~150, APR 2019, s.~141-148. ISSN~0954-6111. Dostupné z: https://doi.org/10.1016/j.rmed.2019.03.007.

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