FAJKUS, Petr, Vratislav PEŠKA, Michal ZÁVODNÍK, Miloslava FOJTOVÁ, Jana FULNEČKOVÁ, Šimon DOBIAS, Agata Magdalena KILAR, Martina DVOŘÁČKOVÁ, Dagmar ZACHOVÁ, Ivona NEČASOVÁ, Jason SIMS, Eva SÝKOROVÁ a Jiří FAJKUS. Telomerase RNAs in land plants. Nucleic acids research. Oxford: Oxford University Press, 2019, roč. 47, č. 18, s. 9842-9856. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkz695. |
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@article{1561456, author = {Fajkus, Petr and Peška, Vratislav and Závodník, Michal and Fojtová, Miloslava and Fulnečková, Jana and Dobias, Šimon and Kilar, Agata Magdalena and Dvořáčková, Martina and Zachová, Dagmar and Nečasová, Ivona and Sims, Jason and Sýkorová, Eva and Fajkus, Jiří}, article_location = {Oxford}, article_number = {18}, doi = {http://dx.doi.org/10.1093/nar/gkz695}, keywords = {Telomerase RNA subunit; plant}, language = {eng}, issn = {0305-1048}, journal = {Nucleic acids research}, title = {Telomerase RNAs in land plants}, url = {https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz695/5545009}, volume = {47}, year = {2019} }
TY - JOUR ID - 1561456 AU - Fajkus, Petr - Peška, Vratislav - Závodník, Michal - Fojtová, Miloslava - Fulnečková, Jana - Dobias, Šimon - Kilar, Agata Magdalena - Dvořáčková, Martina - Zachová, Dagmar - Nečasová, Ivona - Sims, Jason - Sýkorová, Eva - Fajkus, Jiří PY - 2019 TI - Telomerase RNAs in land plants JF - Nucleic acids research VL - 47 IS - 18 SP - 9842-9856 EP - 9842-9856 PB - Oxford University Press SN - 03051048 KW - Telomerase RNA subunit KW - plant UR - https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz695/5545009 L2 - https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz695/5545009 N2 - To elucidate the molecular nature of evolutionary changes of telomeres in the plant order Asparagales, we aimed to characterize telomerase RNA subunits (TRs) in these plants. The unusually long telomere repeat unit in Allium plants (12 nt) allowed us to identify TRs in transcriptomic data of representative species of the Allium genus. Orthologous TRs were then identified in Asparagales plants harbouring telomere DNA composed of TTAGGG (human type) or TTTAGGG (Arabidopsis-type) repeats. Further, we identified TRs across the land plant phylogeny, including common model plants, crop plants, and plants with unusual telomeres. Several lines of functional testing demonstrate the templating telomerase function of the identified TRs and disprove a functionality of the only previously reported plant telomerase RNA in Arabidopsis thaliana. Importantly, our results change the existing paradigm in plant telomere biology which has been based on the existence of a relatively conserved telomerase reverse transcriptase subunit (TERT) associating with highly divergent TRs even between closely related plant taxa. The finding of a monophyletic origin of genuine TRs across land plants opens the possibility to identify TRs directly in transcriptomic or genomic data and/or predict telomere sequences synthesized according to the respective TR template region. ER -
FAJKUS, Petr, Vratislav PEŠKA, Michal ZÁVODNÍK, Miloslava FOJTOVÁ, Jana FULNEČKOVÁ, Šimon DOBIAS, Agata Magdalena KILAR, Martina DVOŘÁČKOVÁ, Dagmar ZACHOVÁ, Ivona NEČASOVÁ, Jason SIMS, Eva SÝKOROVÁ a Jiří FAJKUS. Telomerase RNAs in land plants. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2019, roč.~47, č.~18, s.~9842-9856. ISSN~0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkz695.
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