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@article{1566136,
author = {Havránková, Eva and Csöllei, Jozef and Pazdera, Pavel},
article_location = {Basel},
article_number = {19},
doi = {http://dx.doi.org/10.3390/molecules24193586},
keywords = {1 3 5-triazine; supported Cu(I) catalyst; Ullmann reaction; one-pot synthesis},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804075/},
volume = {24},
year = {2019}
}
TY - JOUR
ID - 1566136
AU - Havránková, Eva - Csöllei, Jozef - Pazdera, Pavel
PY - 2019
TI - New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study
JF - Molecules
VL - 24
IS - 19
SP - 1-10
EP - 1-10
PB - MDPI
SN - 14203049
KW - 1 3 5-triazine
KW - supported Cu(I) catalyst
KW - Ullmann reaction
KW - one-pot synthesis
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804075/
L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804075/
N2 - An efficient and simple methodology for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and corresponding nucleophiles is reported. Cations Cu(I) supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted s-triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new s-triazine derivatives with potential biological activity were prepared and characterized.
ER -
HAVRÁNKOVÁ, Eva, Jozef CSÖLLEI a Pavel PAZDERA. New Approach for the One-Pot Synthesis of 1,3,5-Triazine Derivatives: Application of Cu(I) Supported on a Weakly Acidic Cation-Exchanger Resin in a Comparative Study. \textit{Molecules}. Basel: MDPI, roč.~24, č.~19, s.~1-10. ISSN~1420-3049. doi:10.3390/molecules24193586. 2019.
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