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@article{1566639,
author = {Besse, Lenka and Besse, Andrej and MendezandLopez, Max and Vašíčková, Kateřina and Sedláčková, Miroslava and Vaňhara, Petr and Kraus, Marianne and Bader, Jurgen and Ferreira, Renan B. and Castellano, Ronald K. and Law, Brian K. and Driessen, Christoph},
article_location = {PAVIA},
article_number = {9},
doi = {http://dx.doi.org/10.3324/haematol.2018.207704},
keywords = {metabolic switch; proteasome inhibitor; multiple myeloma},
language = {eng},
issn = {0390-6078},
journal = {Haematologica},
title = {A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis},
url = {http://dx.doi.org/10.3324/haematol.2018.207704},
volume = {104},
year = {2019}
}
TY - JOUR
ID - 1566639
AU - Besse, Lenka - Besse, Andrej - Mendez-Lopez, Max - Vašíčková, Kateřina - Sedláčková, Miroslava - Vaňhara, Petr - Kraus, Marianne - Bader, Jurgen - Ferreira, Renan B. - Castellano, Ronald K. - Law, Brian K. - Driessen, Christoph
PY - 2019
TI - A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis
JF - Haematologica
VL - 104
IS - 9
SP - 415-419
EP - 415-419
PB - FERRATA STORTI FOUNDATION
SN - 03906078
KW - metabolic switch
KW - proteasome inhibitor
KW - multiple myeloma
UR - http://dx.doi.org/10.3324/haematol.2018.207704
L2 - http://dx.doi.org/10.3324/haematol.2018.207704
N2 - Proteasome inhibitors (PI) have evolved as the central backbone of treatment for multiple myeloma (MM), with first-in-class bortezomib and second- and third-generation PI, carfilzomib and ixazomib, having been approved for this indication. Proteasome inhibition disrupts the unfolded protein response to resolve excessive endoplasmic reticulum stress, but also leads to massive metabolic changes manifested by the induction of amino acid biosynthesis, an anti-oxidant response, lipogenesis and an increase in protein folding. In this sense, PI represent a unique class of drugs targeting cancer cell metabolism by affecting the balance between protein biosynthesis, folding and destruction. However, the adaptive changes in MM cell metabolism may provide the basis of resistance to PI, as high glycolytic activity or rewiring glucose metabolism is associated with bortezomib resistance in MM.
ER -
BESSE, Lenka, Andrej BESSE, Max MENDEZ-LOPEZ, Kateřina VAŠÍČKOVÁ, Miroslava SEDLÁČKOVÁ, Petr VAŇHARA, Marianne KRAUS, Jurgen BADER, Renan B. FERREIRA, Ronald K. CASTELLANO, Brian K. LAW a Christoph DRIESSEN. A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis. \textit{Haematologica}. PAVIA: FERRATA STORTI FOUNDATION, 2019, roč.~104, č.~9, s.~415-419. ISSN~0390-6078. Dostupné z: https://dx.doi.org/10.3324/haematol.2018.207704.
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