| SZADVÁRI, Ivan, Soňa HUDECOVÁ, Barbora CHOVANCOVÁ, Miroslava MATÚŠKOVÁ, Dana CHOLUJOVÁ, Ľubomíra LENČEŠOVA, David VALERIÁN, Karol ONDRIAS, Petr BABULA and Oľga KRIŽANOVÁ. Sodium/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019, vol. 87, JUN 1 2019, p. 1-9. ISSN 1089-8603. Available from: https://dx.doi.org/10.1016/j.niox.2019.02.011. |
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@article{1572158,
author = {Szadvári, Ivan and Hudecová, Soňa and Chovancová, Barbora and Matúšková, Miroslava and Cholujová, Dana and Lenčešova, Ľubomíra and Valerián, David and Ondrias, Karol and Babula, Petr and Križanová, Oľga},
article_location = {SAN DIEGO},
article_number = {JUN 1 2019},
doi = {http://dx.doi.org/10.1016/j.niox.2019.02.011},
keywords = {Apoptosis; Hydrogen sulfide; Intracellular acidification; Sodium/calcium exchanger; Sodium/hydrogen exchanger},
language = {eng},
issn = {1089-8603},
journal = {NITRIC OXIDE-BIOLOGY AND CHEMISTRY},
title = {Sodium/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH},
url = {https://www.sciencedirect.com/science/article/pii/S1089860318303343?via%3Dihub},
volume = {87},
year = {2019}
}
TY - JOUR
ID - 1572158
AU - Szadvári, Ivan - Hudecová, Soňa - Chovancová, Barbora - Matúšková, Miroslava - Cholujová, Dana - Lenčešova, Ľubomíra - Valerián, David - Ondrias, Karol - Babula, Petr - Križanová, Oľga
PY - 2019
TI - Sodium/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH
JF - NITRIC OXIDE-BIOLOGY AND CHEMISTRY
VL - 87
IS - JUN 1 2019
SP - 1-9
EP - 1-9
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 10898603
KW - Apoptosis
KW - Hydrogen sulfide
KW - Intracellular acidification
KW - Sodium/calcium exchanger
KW - Sodium/hydrogen exchanger
UR - https://www.sciencedirect.com/science/article/pii/S1089860318303343?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1089860318303343?via%3Dihub
N2 - We explored possibility that sodium/calcium exchanger 1 (NCX1) is involved in pH modulation and apoptosis induction in GYY4137 treated cells. We have shown that although 10 days treatment with GYY4137 did not significantly decreased volume of tumors induced by colorectal cancer DLD1 cells in nude mice, it already induced apoptosis in these tumors. Treatment of DLD1 and ovarian cancer A2780 cells with GYY4137 resulted in intracellular acidification in a concentration-dependent manner. We observed increased mRNA and protein expression of both, NCX1 and sodium/hydrogen exchanger 1 (NHE1) in DLD1-induced tumors from GYY4137-treated mice. NCX1 was coupled with NHE1 in A2780 and DLD1 cells and this complex partially disintegrated after GYY4137 treatment. We proposed that intracellular acidification is due to uncoupling of NCX1/NHE1 complex rather than blocking of the reverse mode of NCX1, probably due to internalization of NHE1. Results might contribute to understanding molecular mechanism of H2S induced apoptosis in tumor cells.
ER -
SZADVÁRI, Ivan, Soňa HUDECOVÁ, Barbora CHOVANCOVÁ, Miroslava MATÚŠKOVÁ, Dana CHOLUJOVÁ, Ľubomíra LENČEŠOVA, David VALERIÁN, Karol ONDRIAS, Petr BABULA and Oľga KRIŽANOVÁ. Sodium/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH. \textit{NITRIC OXIDE-BIOLOGY AND CHEMISTRY}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019, vol.~87, JUN 1 2019, p.~1-9. ISSN~1089-8603. Available from: https://dx.doi.org/10.1016/j.niox.2019.02.011.
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