Correlation of Vitreous Vascular Endothelial Growth Factor and
Uric Acid Concentration Using Optical Coherence Tomography in
Diabetic Macular Edema

J 2015

Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema

KRIZOVA, Libuse; Marta KALOUSOVA; Ales Antonin KUBENA; Oldřich CHRAPEK; Barbora CHRAPKOVA et al.

Základní údaje

Originální název

Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema

Autoři

KRIZOVA, Libuse; Marta KALOUSOVA; Ales Antonin KUBENA; Oldřich CHRAPEK; Barbora CHRAPKOVA; Martin SIN a Tomas ZIMA

Vydání

Journal of Ophthalmology, New York, Hindawi, 2015, 2090-004X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.463

Označené pro přenos do RIV

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 11. 2019 13:00, Mgr. Tereza Miškechová

Anotace

V originále

Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p < 0.001), UA (p = 0.038), and total protein (p < 0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF ((sic) = 0.559, p = 0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV ((sic) = 0.515/p = 0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.

Citovat

KRIZOVA, Libuse; Marta KALOUSOVA; Ales Antonin KUBENA; Oldřich CHRAPEK; Barbora CHRAPKOVA; Martin SIN a Tomas ZIMA. Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema. Journal of Ophthalmology. New York: Hindawi, 2015, s. 1-7. ISSN 2090-004X. Dostupné z: https://doi.org/10.1155/2015/478509.

@article{1578717,
   author = {Krizova, Libuse and Kalousova, Marta and Kubena, Ales Antonin and Chrapek, Oldřich and Chrapkova, Barbora and Sin, Martin and Zima, Tomas},
   article_location = {New York},
   doi = {https://doi.org/10.1155/2015/478509},
   language = {eng},
   issn = {2090-004X},
   journal = {Journal of Ophthalmology},
   note = {Bez afiliace k MU.},
   title = {Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema},
   url = {http://dx.doi.org/10.1155/2015/478509},
   year = {2015}
}

TY  - JOUR
ID  - 1578717
AU  - Krizova, Libuse - Kalousova, Marta - Kubena, Ales Antonin - Chrapek, Oldřich - Chrapkova, Barbora - Sin, Martin - Zima, Tomas
PY  - 2015
TI  - Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema
JF  - Journal of Ophthalmology
SP  - 1-7
EP  - 1-7
PB  - Hindawi
SN  - 2090004X
N1  - Bez afiliace k MU.
UR  - http://dx.doi.org/10.1155/2015/478509
L2  - http://dx.doi.org/10.1155/2015/478509
N2  - Purpose. We investigated two factors linked to diabetic macular edema (DME), vitreous and serum levels of vascular endothelial growth factor (VEGF) and uric acid (UA) in patients with DME, and compared the results with changes in optical coherence tomography (OCT) and visual acuity (VA). Methods. A prospective study of 29 eyes, 16 cystoid DME and nonproliferative diabetic retinopathy (DR) and 13 nondiabetic controls. Biochemical analysis of vitreous and serum samples was performed and OCT scans were graded according to central retinal thickness (CRT), cube volume (CV), cube average thickness (CAT), and serous retinal detachment (SRD). Results. In DME group, intravitreal concentrations of VEGF (p < 0.001), UA (p = 0.038), and total protein (p < 0.001) were significantly higher than in control group. In DME subjects, intravitreal UA correlated significantly with intravitreal VEGF ((sic) = 0.559, p = 0.03) but not with total vitreous protein and serum UA. Increased intravitreal VEGF in DME group correlated with increase in CV ((sic) = 0.515/p = 0.041). None of the OCT parameters correlated with the VA. Conclusions. The results suggest that the CV might be assessor of anti-VEGF therapy efficacy. Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.
ER  -

KRIZOVA, Libuse; Marta KALOUSOVA; Ales Antonin KUBENA; Oldřich CHRAPEK; Barbora CHRAPKOVA; Martin SIN a Tomas ZIMA. Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema. \textit{Journal of Ophthalmology}. New York: Hindawi, 2015, s.~1-7. ISSN~2090-004X. Dostupné z: https://doi.org/10.1155/2015/478509.

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