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@article{1582276,
author = {Munster, Lukas and Fojtů, Michaela and Capakova, Zdenka and Vaculovič, Tomáš and Tvrdoňová, Michaela and Kuritka, Ivo and Masařík, Michal and Vicha, Jan},
article_location = {Washington},
article_number = {4},
doi = {http://dx.doi.org/10.1021/acs.biomac.8b01807},
keywords = {NMR CHEMICAL-SHIFTS; DENSITY-FUNCTIONAL THEORY; RELATIVISTIC DOUBLE-ZETA; HYALURONIC-ACID; DIALDEHYDE CELLULOSE; TRIPLE-ZETA; BASIS-SETS; PT-195 NMR; CISPLATIN; PERIODATE},
language = {eng},
issn = {1525-7797},
journal = {Biomacromolecules},
title = {Selectively Oxidized Cellulose with Adjustable Molecular Weight for Controlled Release of Platinum Anticancer Drugs},
url = {http://dx.doi.org/10.1021/acs.biomac.8b01807},
volume = {20},
year = {2019}
}
TY - JOUR
ID - 1582276
AU - Munster, Lukas - Fojtů, Michaela - Capakova, Zdenka - Vaculovič, Tomáš - Tvrdoňová, Michaela - Kuritka, Ivo - Masařík, Michal - Vicha, Jan
PY - 2019
TI - Selectively Oxidized Cellulose with Adjustable Molecular Weight for Controlled Release of Platinum Anticancer Drugs
JF - Biomacromolecules
VL - 20
IS - 4
SP - 1623-1634
EP - 1623-1634
PB - American Chemical Society
SN - 15257797
KW - NMR CHEMICAL-SHIFTS
KW - DENSITY-FUNCTIONAL THEORY
KW - RELATIVISTIC DOUBLE-ZETA
KW - HYALURONIC-ACID
KW - DIALDEHYDE CELLULOSE
KW - TRIPLE-ZETA
KW - BASIS-SETS
KW - PT-195 NMR
KW - CISPLATIN
KW - PERIODATE
UR - http://dx.doi.org/10.1021/acs.biomac.8b01807
L2 - http://dx.doi.org/10.1021/acs.biomac.8b01807
N2 - The synthesis of selectively oxidized cellulose, 2,3-dicarboxycellulose (DCC), is optimized for preparation of highly oxidized material for biological applications, which includes control over the molecular weight of the product during its synthesis. Conjugates of DCC and cisplatin simultaneously offer a very high drug binding efficiency (>90%) and drug loading capacity (up to 50 wt %), while retaining good aqueous solubility. The adjustable molecular weight of the DCC together with variances in drug feeding ratio allows to optimize cisplatin release profiles from delayed (<2% of cisplatin released during 6 h) to classical burst release with more than 60% of cisplatin released after 24 h. The release rates are also pH-dependent (up to 2 times faster release at pH 5.5 than at pH 7.4), which allows to exploit the acidic nature of tumor microenvironment. Extensive in vitro studies were performed on eight different cell lines for two cisplatin-DCC conjugates with different release profiles. In comparison with free cisplatin, both cisplatin-DCC conjugates demonstrated considerably lower cytotoxicity toward healthy cells. Conjugates with burst release profiles were found more effective against prostate cell lines, while DCC conjugates with slower release were more cytotoxic against ovarian and lung carcinoma cell lines. In vivo studies indicated a significantly longer survival rate, a reduction in tumor volume, and a higher accumulation of platinum in tumors of mice treated with the cisplatin-DCC conjugate in comparison to those treated by free cisplatin.
ER -
MUNSTER, Lukas, Michaela FOJTŮ, Zdenka CAPAKOVA, Tomáš VACULOVIČ, Michaela TVRDOŇOVÁ, Ivo KURITKA, Michal MASAŘÍK a Jan VICHA. Selectively Oxidized Cellulose with Adjustable Molecular Weight for Controlled Release of Platinum Anticancer Drugs. \textit{Biomacromolecules}. Washington: American Chemical Society, 2019, roč.~20, č.~4, s.~1623-1634. ISSN~1525-7797. Dostupné z: https://dx.doi.org/10.1021/acs.biomac.8b01807.
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