| VŠIANSKÝ, Vít, Markéta SVOBODOVÁ, Jaromír GUMULEC, Natalia CERNEI, Dagmar STERBOVA, Ondrej ZITKA, Rom KOSTRICA, Pavel SMILEK, Jan PLZAK, Jan BETKA, David KALFERT, Michal MASAŘÍK a Martina RAUDENSKÁ. Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers. Cells. Basel: MDPI, 2019, roč. 8, č. 5, s. 1-12. ISSN 2073-4409. Dostupné z: https://dx.doi.org/10.3390/cells8050428. |
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@article{1582324,
author = {Všianský, Vít and Svobodová, Markéta and Gumulec, Jaromír and Cernei, Natalia and Sterbova, Dagmar and Zitka, Ondrej and Kostrica, Rom and Smilek, Pavel and Plzak, Jan and Betka, Jan and Kalfert, David and Masařík, Michal and Raudenská, Martina},
article_location = {Basel},
article_number = {5},
doi = {http://dx.doi.org/10.3390/cells8050428},
keywords = {head and neck cancer; blood biomarkers; prognosis; colony forming assay; metabolism; amino acids},
language = {eng},
issn = {2073-4409},
journal = {Cells},
title = {Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers},
url = {http://dx.doi.org/10.3390/cells8050428},
volume = {8},
year = {2019}
}
TY - JOUR
ID - 1582324
AU - Všianský, Vít - Svobodová, Markéta - Gumulec, Jaromír - Cernei, Natalia - Sterbova, Dagmar - Zitka, Ondrej - Kostrica, Rom - Smilek, Pavel - Plzak, Jan - Betka, Jan - Kalfert, David - Masařík, Michal - Raudenská, Martina
PY - 2019
TI - Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers
JF - Cells
VL - 8
IS - 5
SP - 1-12
EP - 1-12
PB - MDPI
SN - 20734409
KW - head and neck cancer
KW - blood biomarkers
KW - prognosis
KW - colony forming assay
KW - metabolism
KW - amino acids
UR - http://dx.doi.org/10.3390/cells8050428
L2 - http://dx.doi.org/10.3390/cells8050428
N2 - Despite distinctive advances in the field of head and neck squamous cell cancer (HNSCC) biomarker discovery, the spectrum of clinically useful prognostic serum biomarkers is limited. As metabolic activities in highly proliferative transformed cells are fundamentally different from those in non-transformed cells, specific shifts in concentration of different metabolites may serve as diagnostic or prognostic markers. Blood amino acids have been identified as promising biomarkers in different cancers before, but little is known about this field in HNSCC. Blood amino acid profiles of 140 HNSCC patients were examined using high-performance liquid chromatography. Cox proportional hazards regression model was used to assess the prognostic value of amino acid concentrations in serum. Colony forming assay was used to identify the effect of amino acids that were significant in Cox proportional hazards regression models on colony forming ability of FaDu and Detroit 562 cell lines. In the multivariable Cox regression model for overall survival (OS), palliative treatment was associated with an unfavourable prognosis while high serum levels of methionine have had a positive prognostic impact. In the relapse-free survival (RFS) multivariable model, methionine was similarly identified as a positive prognostic factor, along with tumor localization in the oropharynx. Oral cavity localization and primary radio(chemo)therapy treatment strategy have been linked to poorer RFS. 1mM serine was shown to support the forming of colonies in both tested HNSCC cell lines. Effect of methionine was exactly the opposite.
ER -
VŠIANSKÝ, Vít, Markéta SVOBODOVÁ, Jaromír GUMULEC, Natalia CERNEI, Dagmar STERBOVA, Ondrej ZITKA, Rom KOSTRICA, Pavel SMILEK, Jan PLZAK, Jan BETKA, David KALFERT, Michal MASAŘÍK a Martina RAUDENSKÁ. Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers. \textit{Cells}. Basel: MDPI, 2019, roč.~8, č.~5, s.~1-12. ISSN~2073-4409. Dostupné z: https://dx.doi.org/10.3390/cells8050428.
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