Gray Matter Changes in Parkinson's and Alzheimer's Disease and
Relation to Cognition

J 2019

Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition

KRAJČOVIČOVÁ, Lenka; Patrícia KLOBUŠIAKOVÁ a Irena REKTOROVÁ

Základní údaje

Originální název

Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition

Autoři

KRAJČOVIČOVÁ, Lenka; Patrícia KLOBUŠIAKOVÁ a Irena REKTOROVÁ

Vydání

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, NEW YORK, SPRINGER, 2019, 1528-4042

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.376

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/19:00108545

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Parkinson's disease; Alzheimer's disease; Gray matter atrophy; Cognition; Structural magnetic resonance imaging

Štítky

14110127, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 5. 2020 13:29, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Purpose of Review We summarize structural (s)MRI findings of gray matter (GM) atrophy related to cognitive impairment in Alzheimer's disease (AD) and Parkinson's disease (PD) in light of new analytical approaches and recent longitudinal studies results. Recent Findings The hippocampus-to-cortex ratio seems to be the best sMRI biomarker to discriminate between various AD subtypes, following the spatial distribution of tau pathology, and predict rate of cognitive decline. PD is clinically far more variable than AD, with heterogeneous underlying brain pathology. Novel multivariate approaches have been used to describe patterns of early subcortical and cortical changes that relate to more malignant courses of PD. New emerging analytical approaches that combine structural MRI data with clinical and other biomarker outcomes hold promise for detecting specific GM changes in the early stages of PD and preclinical AD that may predict mild cognitive impairment and dementia conversion.

Návaznosti

EF16_013/0001775, projekt VaV

Název: Modernizace a podpora výzkumných aktivit národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging

NV16-31868A, projekt VaV

Název: Ovlivnění kognitivních funkcí a konektivity mozku pomocí neinvazivní mozkové stimulace u pacientů s mírnou kognitivní poruchou u Alzheimerovy choroby

734718, interní kód MU

Název: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Akronym: CoBeN)

Investor: Evropská unie, Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Přiložené soubory

Krajcovicova2019_Article_GrayMatterChangesInParkinsonSA.pdf Verze souboru

Citovat

KRAJČOVIČOVÁ, Lenka; Patrícia KLOBUŠIAKOVÁ a Irena REKTOROVÁ. Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. NEW YORK: SPRINGER, 2019, roč. 19, č. 11, s. 1-9. ISSN 1528-4042. Dostupné z: https://doi.org/10.1007/s11910-019-1006-z.

@article{1587581,
   author = {Krajčovičová, Lenka and Klobušiaková, Patrícia and Rektorová, Irena},
   article_location = {NEW YORK},
   article_number = {11},
   doi = {https://doi.org/10.1007/s11910-019-1006-z},
   keywords = {Parkinson's disease; Alzheimer's disease; Gray matter atrophy; Cognition; Structural magnetic resonance imaging},
   language = {eng},
   issn = {1528-4042},
   journal = {CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS},
   title = {Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition},
   url = {http://dx.doi.org/10.1007/s11910-019-1006-z},
   volume = {19},
   year = {2019}
}

TY  - JOUR
ID  - 1587581
AU  - Krajčovičová, Lenka - Klobušiaková, Patrícia - Rektorová, Irena
PY  - 2019
TI  - Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition
JF  - CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
VL  - 19
IS  - 11
SP  - 1-9
EP  - 1-9
PB  - SPRINGER
SN  - 15284042
KW  - Parkinson's disease
KW  - Alzheimer's disease
KW  - Gray matter atrophy
KW  - Cognition
KW  - Structural magnetic resonance imaging
UR  - http://dx.doi.org/10.1007/s11910-019-1006-z
L2  - http://dx.doi.org/10.1007/s11910-019-1006-z
N2  - Purpose of Review We summarize structural (s)MRI findings of gray matter (GM) atrophy related to cognitive impairment in Alzheimer's disease (AD) and Parkinson's disease (PD) in light of new analytical approaches and recent longitudinal studies results. Recent Findings The hippocampus-to-cortex ratio seems to be the best sMRI biomarker to discriminate between various AD subtypes, following the spatial distribution of tau pathology, and predict rate of cognitive decline. PD is clinically far more variable than AD, with heterogeneous underlying brain pathology. Novel multivariate approaches have been used to describe patterns of early subcortical and cortical changes that relate to more malignant courses of PD. New emerging analytical approaches that combine structural MRI data with clinical and other biomarker outcomes hold promise for detecting specific GM changes in the early stages of PD and preclinical AD that may predict mild cognitive impairment and dementia conversion.
ER  -

KRAJČOVIČOVÁ, Lenka; Patrícia KLOBUŠIAKOVÁ a Irena REKTOROVÁ. Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition. \textit{CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS}. NEW YORK: SPRINGER, 2019, roč.~19, č.~11, s.~1-9. ISSN~1528-4042. Dostupné z: https://doi.org/10.1007/s11910-019-1006-z.

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