Impaired post-irradiation survival of cyclooxygenase-2-deficient mice

HOFER, Michal, Z HOFEROVÁ, A GRUZDEV, Ladislav DUŠEK and Martin FALK. Impaired post-irradiation survival of cyclooxygenase-2-deficient mice. Physiological Research. 2018, vol. 67, No 5, p. 809-812.

Basic information

Original name

Impaired post-irradiation survival of cyclooxygenase-2-deficient mice

Authors

HOFER, Michal, Z HOFEROVÁ, A GRUZDEV, Ladislav DUŠEK and Martin FALK

Edition

Physiological Research, 2018

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Tags

International impact, Reviewed

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Abstract

V originále

We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of γ-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.