Pharmacological modulation of radiation damage. Does it exist a
chance for other substances thanhematopoietic growth factors
and cytokines?

J 2017

Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?

HOFER, Michal; Z HOFEROVÁ a Martin FALK

Základní údaje

Originální název

Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?

Autoři

HOFER, Michal; Z HOFEROVÁ a Martin FALK

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2017, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

DOI

http://dx.doi.org/10.3390/ijms18071385

UT WoS

000408746800057

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 12. 2019 13:42, doc. RNDr. Martin Falk, Ph.D.

Anotace

V originále

In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider β-glucan, 5-AED (5-androstenediol), meloxicam, γ-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl)adenosine-5’-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.

Návaznosti

GA16-12454S, projekt VaV

Název: Charakterizace a modifikace komplexní odpovědi buněk nádorů hlavy a krku na různá záření - krok kupředu ke kombinované personalizované (radio)terapii

Investor: Grantová agentura ČR, Charakterizace a modifikace komplexní odpovědi buněk nádorů hlavy a krku na různá záření - krok kupředu ke kombinované personalizované (radio)terapii

NV16-29835A, projekt VaV

Název: Molekulárně-genetické markery predikce účinnosti radioterapie u nádorů hlavy a krku

Citovat

HOFER, Michal; Z HOFEROVÁ a Martin FALK. Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines? International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2017, roč. 18, č. 7, s. art. no. 1385. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms18071385.

@article{1594203,
   author = {Hofer, Michal and Hoferová, Z and Falk, Martin},
   article_location = {Basel},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/ijms18071385},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?},
   url = {http://dx.doi.org/10.3390/ijms18071385},
   volume = {18},
   year = {2017}
}

TY  - JOUR
ID  - 1594203
AU  - Hofer, Michal - Hoferová, Z - Falk, Martin
PY  - 2017
TI  - Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?
JF  - International Journal of Molecular Sciences
VL  - 18
IS  - 7
SP  - art. no. 1385
EP  - art. no. 1385
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
UR  - http://dx.doi.org/10.3390/ijms18071385
L2  - http://dx.doi.org/10.3390/ijms18071385
N2  - In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider β-glucan, 5-AED (5-androstenediol), meloxicam, γ-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl)adenosine-5’-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.
ER  -

HOFER, Michal; Z HOFEROVÁ a Martin FALK. Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines? \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2017, roč.~18, č.~7, s.~art. no. 1385. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms18071385.

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