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@article{1594220,
author = {Falk, Martin and Hausmann, M and Lukášová, Emilie and Biswas, A and Hildenbrand, G and Davídková, M and Krasavin, E Kleibl Z and Falková, I and Ježková, L and Štefančíková, L and Ševčík, J and Hofer, Michal and Bačíková, A and Matula, P Boreyko A and Vachelová, J and Michaelidesová, A and Kozubek, Stanislav},
article_number = {3},
doi = {http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2014010313},
language = {eng},
journal = {Critical Reviews in Eukaryotic Gene Expression},
title = {Determining Omics spatiotemporal dimensions using exciting new nanoscopy techniques to assesscomplex cell responses to DNA damage: PART A-radiomics},
volume = {24},
year = {2014}
}
TY - JOUR
ID - 1594220
AU - Falk, Martin - Hausmann, M - Lukášová, Emilie - Biswas, A - Hildenbrand, G - Davídková, M - Krasavin, E Kleibl Z - Falková, I - Ježková, L - Štefančíková, L - Ševčík, J - Hofer, Michal - Bačíková, A - Matula, P Boreyko A - Vachelová, J - Michaelidesová, A - Kozubek, Stanislav
PY - 2014
TI - Determining Omics spatiotemporal dimensions using exciting new nanoscopy techniques to assesscomplex cell responses to DNA damage: PART A-radiomics
JF - Critical Reviews in Eukaryotic Gene Expression
VL - 24
IS - 3
SP - 205-223
EP - 205-223
N2 - Recent ground-breaking developments in Omics have generated new hope for overcoming the complexity and variability of biological systems while simultaneously shedding more light on fundamental radiobiological questions that have remained unanswered for decades. In the era of Omics, our knowledge of how genes and proteins interact in the frame of complex networks to preserve genome integrity has been rapidly expanding. Nevertheless, these functional networks must be observed with strong correspondence to the cell nucleus, which is the main target of ionizing radiation. Nuclear architecture and nuclear processes, including DNA damage responses, are precisely organized in space and time. Information regarding these intricate processes cannot be achieved using high-throughput Omics approaches alone, but requires sophisticated structural probing and imaging. Based on the results obtained from studying the relationship between higher-order chromatin structure, DNA double-strand break induction and repair, and the formation of chromosomal translocations, we show the development of Omics solutions especially for radiation research (radiomics) (discussed in this article) and how confocal microscopy as well as novel approaches of molecular localization nanoscopy fill the gaps to successfully place the Omics data in the context of space and time (discussed in our other article in this issue, "Determining Omics Spatiotemporal Dimensions Using Exciting New Nanoscopy Techniques to Assess Complex Cell Responses to DNA Damage: Part B-Structuromics"). Finally, we introduce a novel method of specific chromatin nanotargeting and speculate future perspectives, which may combine nanoprobing and structural nanoscopy to observe structure-function correlations in living cells in real time. Thus, the Omics networks obtained from function analyses may be enriched by real-time visualization of Structuromics.
ER -
FALK, Martin, M HAUSMANN, Emilie LUKÁŠOVÁ, A BISWAS, G HILDENBRAND, M DAVÍDKOVÁ, E Kleibl Z KRASAVIN, I FALKOVÁ, L JEŽKOVÁ, L ŠTEFANČÍKOVÁ, J ŠEVČÍK, Michal HOFER, A BAČÍKOVÁ, P Boreyko A MATULA, J VACHELOVÁ, A MICHAELIDESOVÁ a Stanislav KOZUBEK. Determining Omics spatiotemporal dimensions using exciting new nanoscopy techniques to assesscomplex cell responses to DNA damage: PART A-radiomics. \textit{Critical Reviews in Eukaryotic Gene Expression}. 2014, roč.~24, č.~3, s.~205-223. Dostupné z: https://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2014010313.
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