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@article{1594258,
author = {Janeckova, Lucie and Kolar, Michal and Svec, Jiri and Lanikova, Lucie and Pospíchalová, Vendula and Baloghova, Nikol and Vojtechova, Martina and Sloncova, Eva and Strnad, Hynek and Korinek, Vladimir},
article_location = {New York},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.tranon.2016.01.005},
keywords = {Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays},
language = {eng},
issn = {1936-5233},
journal = {TRANSLATIONAL ONCOLOGY},
title = {HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833890/pdf/main.pdf},
volume = {9},
year = {2016}
}
TY - JOUR
ID - 1594258
AU - Janeckova, Lucie - Kolar, Michal - Svec, Jiri - Lanikova, Lucie - Pospíchalová, Vendula - Baloghova, Nikol - Vojtechova, Martina - Sloncova, Eva - Strnad, Hynek - Korinek, Vladimir
PY - 2016
TI - HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
JF - TRANSLATIONAL ONCOLOGY
VL - 9
IS - 2
SP - 99-107
EP - 99-107
PB - ELSEVIER SCIENCE INC
SN - 19365233
KW - Apoptosis
KW - Bnip3L
KW - caspase-12
KW - hair follicles
KW - PCR arrays
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833890/pdf/main.pdf
L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833890/pdf/main.pdf
N2 - Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
ER -
JANECKOVA, Lucie, Michal KOLAR, Jiri SVEC, Lucie LANIKOVA, Vendula POSPÍCHALOVÁ, Nikol BALOGHOVA, Martina VOJTECHOVA, Eva SLONCOVA, Hynek STRNAD a Vladimir KORINEK. HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy. \textit{TRANSLATIONAL ONCOLOGY}. New York: ELSEVIER SCIENCE INC, 2016, roč.~9, č.~2, s.~99-107. ISSN~1936-5233. Dostupné z: https://dx.doi.org/10.1016/j.tranon.2016.01.005.
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