The use of micro carbon pencil lead electrode for sensitive
HPLC-ED analysis of selected antipsychotic drugs

J 2020

The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs

RIMAN, Daniel; Jan ROZSYPAL; Vladimír HALOUZKA; Jan HRBÁČ; David JIROVSKÝ et al.

Základní údaje

Originální název

The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs

Autoři

RIMAN, Daniel; Jan ROZSYPAL; Vladimír HALOUZKA; Jan HRBÁČ a David JIROVSKÝ

Vydání

Microchemical Journal, Amsterdam, Elsevier, 2020, 0026-265X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10405 Electrochemistry

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.821

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/20:00115198

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

HPLC; Antipsychotics; Electrochemical detection; Voltammetry; Pencil electrode

Štítky

14313010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 11. 2020 17:58, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Sensitive analysis of nine selected antipsychotic drugs is demonstrated by high performance liquid chromatography coupled with innovative electrochemical detector employing the non standard, 0.2 mm diameter Pentel AinStein pencil graphite as a working electrode. In addition to low cost, the detector performance is characterized by low background current, capability to operate in low ionic strength media and very fast attainment of stable baseline. These advantageous features are attributed to microelectrode character of the pencil lead surface. The concentration LODs ranged between 1.0 (olanzapine) and 7.9 nmol/L (chlorpromazine) with linearity up to 500 nmol/L . Model analyses in spiked control serum as well as the real sample analyses of human plasma samples of subjects after intoxication with olanzapine resp. promethazine are shown. According to relevant assessment tools, the whole procedure can be regarded as green.

Návaznosti

MUNI/A/1359/2018, interní kód MU

Název: Vývoj metod a instrumentace pro analýzu biologicky významných látek 2019

Investor: Masarykova univerzita, Vývoj metod a instrumentace pro analýzu biologicky významných látek 2019, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

RIMAN, Daniel; Jan ROZSYPAL; Vladimír HALOUZKA; Jan HRBÁČ a David JIROVSKÝ. The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs. Microchemical Journal. Amsterdam: Elsevier, 2020, roč. 154, May 2020, s. 1-8. ISSN 0026-265X. Dostupné z: https://doi.org/10.1016/j.microc.2020.104606.

@article{1604497,
   author = {Riman, Daniel and Rozsypal, Jan and Halouzka, Vladimír and Hrbáč, Jan and Jirovský, David},
   article_location = {Amsterdam},
   article_number = {May 2020},
   doi = {https://doi.org/10.1016/j.microc.2020.104606},
   keywords = {HPLC; Antipsychotics; Electrochemical detection; Voltammetry; Pencil electrode},
   language = {eng},
   issn = {0026-265X},
   journal = {Microchemical Journal},
   title = {The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs},
   url = {https://www.sciencedirect.com/science/article/pii/S0026265X19330991?via%3Dihub},
   volume = {154},
   year = {2020}
}

TY  - JOUR
ID  - 1604497
AU  - Riman, Daniel - Rozsypal, Jan - Halouzka, Vladimír - Hrbáč, Jan - Jirovský, David
PY  - 2020
TI  - The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs
JF  - Microchemical Journal
VL  - 154
IS  - May 2020
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 0026265X
KW  - HPLC
KW  - Antipsychotics
KW  - Electrochemical detection
KW  - Voltammetry
KW  - Pencil electrode
UR  - https://www.sciencedirect.com/science/article/pii/S0026265X19330991?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0026265X19330991?via%3Dihub
N2  - Sensitive analysis of nine selected antipsychotic drugs is demonstrated by high performance liquid chromatography coupled with innovative electrochemical detector employing the non standard, 0.2 mm diameter Pentel AinStein pencil graphite as a working electrode. In addition to low cost, the detector performance is characterized by low background current, capability to operate in low ionic strength media and very fast attainment of stable baseline. These advantageous features are attributed to microelectrode character of the pencil lead surface. The concentration LODs ranged between 1.0 (olanzapine) and 7.9 nmol/L (chlorpromazine) with linearity up to 500 nmol/L . Model analyses in spiked control serum as well as the real sample analyses of human plasma samples of subjects after intoxication with olanzapine resp. promethazine are shown. According to relevant assessment tools, the whole procedure can be regarded as green.
ER  -

RIMAN, Daniel; Jan ROZSYPAL; Vladimír HALOUZKA; Jan HRBÁČ a David JIROVSKÝ. The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs. \textit{Microchemical Journal}. Amsterdam: Elsevier, 2020, roč.~154, May 2020, s.~1-8. ISSN~0026-265X. Dostupné z: https://doi.org/10.1016/j.microc.2020.104606.

Přehled o publikaci