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@article{1606900,
author = {Snopková, Svatava and Matýšková, Miloslava and Havlíčková, Kateřina and Jarkovský, Jiří and Svoboda, Michal and Zavřelová, Jiřina and Svačinka, Radek and Penka, Miroslav and Husa, Petr},
article_location = {ISSY-LES-MOULINEAUX},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.medmal.2019.09.013},
keywords = {Antiretroviral therapy; coagulation; HIV; microparticles; non-AIDS diseases},
language = {eng},
issn = {0399-077X},
journal = {Médecine et maladies infectiuses},
title = {Increasing procoagulant activity of circulating microparticles in patients living with HIV},
url = {http://dx.doi.org/10.1016/j.medmal.2019.09.013},
volume = {50},
year = {2020}
}
TY - JOUR
ID - 1606900
AU - Snopková, Svatava - Matýšková, Miloslava - Havlíčková, Kateřina - Jarkovský, Jiří - Svoboda, Michal - Zavřelová, Jiřina - Svačinka, Radek - Penka, Miroslav - Husa, Petr
PY - 2020
TI - Increasing procoagulant activity of circulating microparticles in patients living with HIV
JF - Médecine et maladies infectiuses
VL - 50
IS - 7
SP - 555-561
EP - 555-561
PB - Elsevier France
SN - 0399077X
KW - Antiretroviral therapy
KW - coagulation
KW - HIV
KW - microparticles
KW - non-AIDS diseases
UR - http://dx.doi.org/10.1016/j.medmal.2019.09.013
L2 - http://dx.doi.org/10.1016/j.medmal.2019.09.013
N2 - Objectives Individuals with HIV have a higher risk for non-AIDS diseases associated with procoagulant status. Microparticles are elevated in disorders that are associated with thrombosis (e.g. cardiovascular disease). We investigated the association between microparticle levels in untreated and treated subjects with HIV, and determined the dependence on immune status, viral replication, and duration of antiretroviral therapy. Patients and methods The study was conducted among 144 subjects with HIV, including 123 subjects on antiretroviral therapy and 21 subjects before the initiation of treatment. A control group of 40 healthy HIV-negative adults matched for age and sex was used for comparisons of microparticle levels. Subjects on treatment were divided into five groups depending on the period of antiretroviral exposure. Statistically significant differences were determined by the Kruskal-Wallis test and ML chi-square test. The relationship of microparticles with other parameters was analyzed by Spearman’s coefficient of correlation. Results Microparticle levels were significantly higher in subjects with HIV without treatment and on treatment compared with HIV-negative controls (P < 0.001). The amount of microparticles was similar between the groups on treatment (P = 0.913). No association between microparticle level and CD4+ count, CD4+/CD8+ ratio, number of HIV-1 RNA copies or duration of exposure to antiretroviral treatment was found. Conclusions Increased levels of microparticles might occur by processes independent of viral replication and CD4+ cell count, and microparticle release might persist even during viral suppression by antiretroviral treatment. Elevated microparticle levels might occur in response to other triggers.
ER -
SNOPKOVÁ, Svatava, Miloslava MATÝŠKOVÁ, Kateřina HAVLÍČKOVÁ, Jiří JARKOVSKÝ, Michal SVOBODA, Jiřina ZAVŘELOVÁ, Radek SVAČINKA, Miroslav PENKA a Petr HUSA. Increasing procoagulant activity of circulating microparticles in patients living with HIV. \textit{Médecine et maladies infectiuses}. ISSY-LES-MOULINEAUX: Elsevier France, 2020, roč.~50, č.~7, s.~555-561. ISSN~0399-077X. Dostupné z: https://dx.doi.org/10.1016/j.medmal.2019.09.013.
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