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@article{1607098,
author = {Slouka, David and Kucera, Radek and Gál, Břetislav and Betka, Jaroslav and Skalova, Alena},
article_location = {Munsbach},
article_number = {2},
keywords = {Obstructive sleep apnea syndrome; monitoring; biomarker; blood level; pentraxin-3s},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome},
url = {https://www.ncbi.nlm.nih.gov/pubmed/31785215},
volume = {40},
year = {2019}
}
TY - JOUR
ID - 1607098
AU - Slouka, David - Kucera, Radek - Gál, Břetislav - Betka, Jaroslav - Skalova, Alena
PY - 2019
TI - Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome
JF - Neuroendocrinology Letters
VL - 40
IS - 2
SP - 85-92
EP - 85-92
PB - Maghira & Maas publications
SN - 0172780X
KW - Obstructive sleep apnea syndrome
KW - monitoring
KW - biomarker
KW - blood level
KW - pentraxin-3s
UR - https://www.ncbi.nlm.nih.gov/pubmed/31785215
L2 - https://www.ncbi.nlm.nih.gov/pubmed/31785215
N2 - OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 serum levels and obstructive sleep apnea syndrome. DESIGN: Prospective cohort study. MATERIAL AND METHODS: A group of 146 patients with middle to severe obstructive sleep apnea syndrome (OSAS) were monitored, and the results were compared with the results from a control group of healthy individuals. RESULTS: We assessed serum levels of the following biomarkers: CRP, PTX-3, IL6, hsTnI, BNP, and galectin-3. PTX-3 serum levels were statistically significantly higher (p<0.0001) in patients with OSAS, compared to controls. Statistical results related to the other biomarkers did not suggest any clinical value. ROC analysis showed that PTX-3 might be able to distinguish patients with OSAS from healthy individuals (AUC=7438). CONCLUSION: The elevation of PTX-3 serum levels is significantly associated with middle to severe obstructive sleep apnea syndrome. The PTX-3 biomarker appears to be a promising alternative method for sleep apnea syndrome investigations.
ER -
SLOUKA, David, Radek KUCERA, Břetislav GÁL, Jaroslav BETKA a Alena SKALOVA. Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome. \textit{Neuroendocrinology Letters}. Munsbach: Maghira \&{} Maas publications, 2019, roč.~40, č.~2, s.~85-92. ISSN~0172-780X.
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