Biomarkers - a possibility for monitoring of obstructive sleep
apnea syndrome

J 2019

Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome

SLOUKA, David, Radek KUCERA, Břetislav GÁL, Jaroslav BETKA, Alena SKALOVA et. al.

Základní údaje

Originální název

Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome

Autoři

SLOUKA, David (203 Česká republika, garant), Radek KUCERA (203 Česká republika), Břetislav GÁL (203 Česká republika, domácí), Jaroslav BETKA (203 Česká republika) a Alena SKALOVA (203 Česká republika)

Vydání

Neuroendocrinology Letters, Munsbach, Maghira & Maas publications, 2019, 0172-780X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30206 Otorhinolaryngology

Stát vydavatele

Lucembursko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.750

Kód RIV

RIV/00216224:14110/19:00112627

Organizační jednotka

Lékařská fakulta

UT WoS

000501525000005

Klíčová slova anglicky

Obstructive sleep apnea syndrome; monitoring; biomarker; blood level; pentraxin-3s

Štítky

14110126, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2020 10:45, Mgr. Tereza Miškechová

Anotace

V originále

OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 serum levels and obstructive sleep apnea syndrome. DESIGN: Prospective cohort study. MATERIAL AND METHODS: A group of 146 patients with middle to severe obstructive sleep apnea syndrome (OSAS) were monitored, and the results were compared with the results from a control group of healthy individuals. RESULTS: We assessed serum levels of the following biomarkers: CRP, PTX-3, IL6, hsTnI, BNP, and galectin-3. PTX-3 serum levels were statistically significantly higher (p<0.0001) in patients with OSAS, compared to controls. Statistical results related to the other biomarkers did not suggest any clinical value. ROC analysis showed that PTX-3 might be able to distinguish patients with OSAS from healthy individuals (AUC=7438). CONCLUSION: The elevation of PTX-3 serum levels is significantly associated with middle to severe obstructive sleep apnea syndrome. The PTX-3 biomarker appears to be a promising alternative method for sleep apnea syndrome investigations.

Citovat

SLOUKA, David, Radek KUCERA, Břetislav GÁL, Jaroslav BETKA a Alena SKALOVA. Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome. Neuroendocrinology Letters. Munsbach: Maghira & Maas publications, 2019, roč. 40, č. 2, s. 85-92. ISSN 0172-780X.

@article{1607098,
   author = {Slouka, David and Kucera, Radek and Gál, Břetislav and Betka, Jaroslav and Skalova, Alena},
   article_location = {Munsbach},
   article_number = {2},
   keywords = {Obstructive sleep apnea syndrome; monitoring; biomarker; blood level; pentraxin-3s},
   language = {eng},
   issn = {0172-780X},
   journal = {Neuroendocrinology Letters},
   title = {Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/31785215},
   volume = {40},
   year = {2019}
}

TY  - JOUR
ID  - 1607098
AU  - Slouka, David - Kucera, Radek - Gál, Břetislav - Betka, Jaroslav - Skalova, Alena
PY  - 2019
TI  - Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome
JF  - Neuroendocrinology Letters
VL  - 40
IS  - 2
SP  - 85-92
EP  - 85-92
PB  - Maghira & Maas publications
SN  - 0172780X
KW  - Obstructive sleep apnea syndrome
KW  - monitoring
KW  - biomarker
KW  - blood level
KW  - pentraxin-3s
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31785215
L2  - https://www.ncbi.nlm.nih.gov/pubmed/31785215
N2  - OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 serum levels and obstructive sleep apnea syndrome. DESIGN: Prospective cohort study. MATERIAL AND METHODS: A group of 146 patients with middle to severe obstructive sleep apnea syndrome (OSAS) were monitored, and the results were compared with the results from a control group of healthy individuals. RESULTS: We assessed serum levels of the following biomarkers: CRP, PTX-3, IL6, hsTnI, BNP, and galectin-3. PTX-3 serum levels were statistically significantly higher (p<0.0001) in patients with OSAS, compared to controls. Statistical results related to the other biomarkers did not suggest any clinical value. ROC analysis showed that PTX-3 might be able to distinguish patients with OSAS from healthy individuals (AUC=7438). CONCLUSION: The elevation of PTX-3 serum levels is significantly associated with middle to severe obstructive sleep apnea syndrome. The PTX-3 biomarker appears to be a promising alternative method for sleep apnea syndrome investigations.
ER  -

SLOUKA, David, Radek KUCERA, Břetislav GÁL, Jaroslav BETKA a Alena SKALOVA. Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome. \textit{Neuroendocrinology Letters}. Munsbach: Maghira \&{} Maas publications, 2019, roč.~40, č.~2, s.~85-92. ISSN~0172-780X.

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