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@proceedings{1608524, author = {Midlik, Adam and Hutařová Vařeková, Ivana and Hutař, Jan and Moturu, Tarakaramji and Navrátilová, Veronika and Svobodová Vařeková, Radka and Koča, Jaroslav and Berka, Karel}, booktitle = {National Bioinformatic Conference ENBIK}, language = {eng}, title = {Automated Annotation of Secondary Structure Elements for Entire Protein Families}, url = {http://www.enbik.cz/enbik2018/}, year = {2018} }
TY - CONF ID - 1608524 AU - Midlik, Adam - Hutařová Vařeková, Ivana - Hutař, Jan - Moturu, Tarakaramji - Navrátilová, Veronika - Svobodová Vařeková, Radka - Koča, Jaroslav - Berka, Karel PY - 2018 TI - Automated Annotation of Secondary Structure Elements for Entire Protein Families UR - http://www.enbik.cz/enbik2018/ N2 - Protein structural data, deposited in Protein Data Bank, represent a highly valuable source of information and their amount is continuously growing. Currently, the data contain more and more structurally and functionally similar proteins (so called protein families), which originate from various organisms, contain different ligands, or have various mutations. To analyse and examine these data, we must identify comparable and related regions in different proteins from one protein family. A part of this process is annotation of protein secondary structure elements (SSEs), which form stable parts of the protein and help us to localize the key regions. Since an automated procedure for SSEs annotation is not available yet, we developed such an approach [1]. Our method is template-based, meaning that an annotation of a template protein from the family is provided as an input to the algorithm together with a set of query proteins (the whole family). A three-step algorithm is then executed on each query protein. In the first step, SSEs are detected in the query protein. The second step is structural alignment and superimposition of the query protein and the template protein, so the corresponding parts of the two proteins are located close to each other. The third step is the selection of those SSEs from the query protein which are the best counterparts for the SSEs in the template protein. [1] Svobodová Vařeková, R., Midlik, A., Hutařová Vařeková, I., Hutař, J., Navrátilová, V., Koča, J., Berka, K. (2018). Secondary Structure Elements-Annotations and Schematic 2D Visualizations Stable for Individual Protein Families. Biophysical Journal, 114(3), 46a-47a. ER -
MIDLIK, Adam, Ivana HUTAŘOVÁ VAŘEKOVÁ, Jan HUTAŘ, Tarakaramji MOTURU, Veronika NAVRÁTILOVÁ, Radka SVOBODOVÁ VAŘEKOVÁ, Jaroslav KOČA a Karel BERKA. Automated Annotation of Secondary Structure Elements for Entire Protein Families. In \textit{National Bioinformatic Conference ENBIK}. 2018.
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