Další formáty:
BibTeX
LaTeX
RIS
@article{1609602,
author = {Held, Melissa and Karl, Franziska and Vlčková, Eva and Rajdová, Aneta and EscolanoandLozano, Fabiola and Stetter, Christian and Bharti, Richa and Förstner, Konrad U. and Dušek, Ladislav and Leinders, Mathias and Birklein, Frank and Bednařík, Josef and Sommer, Claudia and Üçeyler, Nurcan},
article_number = {10},
doi = {http://dx.doi.org/10.1097/j.pain.0000000000001623},
keywords = {Nerve lesion; Neuropathic pain; Sensory profile; Quantitative sensory testing; mRNA},
language = {eng},
issn = {0304-3959},
journal = {Pain},
title = {Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion},
url = {http://dx.doi.org/10.1097/j.pain.0000000000001623},
volume = {160},
year = {2019}
}
TY - JOUR
ID - 1609602
AU - Held, Melissa - Karl, Franziska - Vlčková, Eva - Rajdová, Aneta - Escolano-Lozano, Fabiola - Stetter, Christian - Bharti, Richa - Förstner, Konrad U. - Dušek, Ladislav - Leinders, Mathias - Birklein, Frank - Bednařík, Josef - Sommer, Claudia - Üçeyler, Nurcan
PY - 2019
TI - Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion
JF - Pain
VL - 160
IS - 10
SP - 2316-2327
EP - 2316-2327
PB - LIPPINCOTT WILLIAMS & WILKINS
SN - 03043959
KW - Nerve lesion
KW - Neuropathic pain
KW - Sensory profile
KW - Quantitative sensory testing
KW - mRNA
UR - http://dx.doi.org/10.1097/j.pain.0000000000001623
L2 - http://dx.doi.org/10.1097/j.pain.0000000000001623
N2 - In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P , 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P , 0.05 to P , 0.01). Neuropathic pain was frequently accompanied by other chronic pain (P , 0.05). Quantitative sensory testing showed ipsilateral signs of small and large fiber impairment compared to the respective contralateral side, with elevated thermal and mechanical detection thresholds (P , 0.001 to P , 0.05) and lowered pressure pain threshold (P , 0.05). Also, more loss of function was found in patients with NL-1 compared to NL-0. Pain intensity was associated with mechanical hyperalgesia (P , 0.05 to P , 0.01). However, quantitative sensory testing did not detect or predict neuropathic pain. Gene expression of peptidylglycine a-amidating monooxygenase was higher in NL patients compared with healthy controls (NL-1, P , 0.01; NL-0, P , 0.001). Also, gene expression of tumor necrosis factor-a was higher in NL-1 patients compared with NL-0 (P , 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P , 0.05 each). Our study reveals that nerve lesion presents with small and large nerve fiber dysfunction, which may contribute to the presence and intensity of neuropathic pain and which is associated with a systemic proinflammatory pattern.
ER -
HELD, Melissa, Franziska KARL, Eva VLČKOVÁ, Aneta RAJDOVÁ, Fabiola ESCOLANO-LOZANO, Christian STETTER, Richa BHARTI, Konrad U. FÖRSTNER, Ladislav DUŠEK, Mathias LEINDERS, Frank BIRKLEIN, Josef BEDNAŘÍK, Claudia SOMMER a Nurcan Ü$\backslash$C CEYLER. Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion. Online. \textit{Pain}. LIPPINCOTT WILLIAMS \&{} WILKINS, 2019, roč.~160, č.~10, s.~2316-2327. ISSN~0304-3959. Dostupné z: https://dx.doi.org/10.1097/j.pain.0000000000001623. [citováno 2024-04-24]
|
