Kink in Helical Peptides Affects Membrane Pore Formation

a 2019

Kink in Helical Peptides Affects Membrane Pore Formation

TÜRKOVÁ, Alžběta; Ivo KABELKA; Tereza KRÁLOVÁ; Lukáš SUKENÍK; S. POKORNÁ et al.

Základní údaje

Originální název

Kink in Helical Peptides Affects Membrane Pore Formation

Autoři

TÜRKOVÁ, Alžběta; Ivo KABELKA ; Tereza KRÁLOVÁ; Lukáš SUKENÍK ; S. POKORNÁ; M. HOF a Robert VÁCHA

Vydání

2019

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10403 Physical chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Kink in Helical Peptides Affects Membrane Pore Formation

Impakt faktor

Impact factor: 3.854

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/19:00112870

Organizační jednotka

Přírodovědecká fakulta

ISSN

DOI

https://doi.org/10.1016/j.bpj.2018.11.2760

UT WoS

000460779802573

Klíčová slova anglicky

Kink; Helical Peptides

Štítky

rivok

Příznaky

Mezinárodní význam

Změněno: 1. 4. 2020 15:51, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Antimicrobial peptides (AMPs) can kill pathogenic cells via the formation of membrane pores. However, the connection between peptide properties and their effect on pore formation remains elusive. In particular, the role of proline/glycine kink in helical AMPs has been reported with contradictory effects on antimicrobial activity. Using computer simulations and fluorescence leakage experiments we show the relationship between alpha-helical kink and the structure of the formed pore. Reconciling previous data, the presence of kinks was found to have both stabilizing or destabilizing effect, depending on the pore structure. Moreover, the position of proline/glycine kink in AMP sequence controls the peptide arrangements in the stabilized pores. The provided knowledge can be utilized to rationally design peptides with different ability to form membrane pores useful for the development of new antibacterial agents. To read this article in full you will need to make a payment

Citovat

TÜRKOVÁ, Alžběta; Ivo KABELKA; Tereza KRÁLOVÁ; Lukáš SUKENÍK; S. POKORNÁ; M. HOF a Robert VÁCHA. Kink in Helical Peptides Affects Membrane Pore Formation. 2019. ISSN 0006-3495. Dostupné z: https://doi.org/10.1016/j.bpj.2018.11.2760.

@proceedings{1616699,
   author = {Türková, Alžběta and Kabelka, Ivo and Králová, Tereza and Sukeník, Lukáš and Pokorná, S. and Hof, M. and Vácha, Robert},
   doi = {https://doi.org/10.1016/j.bpj.2018.11.2760},
   keywords = {Kink; Helical Peptides},
   language = {eng},
   title = {Kink in Helical Peptides Affects Membrane Pore Formation},
   url = {https://www.cell.com/biophysj/fulltext/S0006-3495(18)34025-6#articleInformation},
   year = {2019}
}

TY  - CONF
ID  - 1616699
AU  - Türková, Alžběta - Kabelka, Ivo - Králová, Tereza - Sukeník, Lukáš - Pokorná, S. - Hof, M. - Vácha, Robert
PY  - 2019
TI  - Kink in Helical Peptides Affects Membrane Pore Formation
KW  - Kink
KW  - Helical Peptides
UR  - https://www.cell.com/biophysj/fulltext/S0006-3495(18)34025-6#articleInformation
L2  - https://www.cell.com/biophysj/fulltext/S0006-3495(18)34025-6#articleInformation
N2  - Antimicrobial peptides (AMPs) can kill pathogenic cells via the formation of membrane pores. However, the connection between peptide properties and their effect on pore formation remains elusive. In particular, the role of proline/glycine kink in helical AMPs has been reported with contradictory effects on antimicrobial activity. Using computer simulations and fluorescence leakage experiments we show the relationship between alpha-helical kink and the structure of the formed pore. Reconciling previous data, the presence of kinks was found to have both stabilizing or destabilizing effect, depending on the pore structure. Moreover, the position of proline/glycine kink in AMP sequence controls the peptide arrangements in the stabilized pores. The provided knowledge can be utilized to rationally design peptides with different ability to form membrane pores useful for the development of new antibacterial agents. To read this article in full you will need to make a payment
ER  -

TÜRKOVÁ, Alžběta; Ivo KABELKA; Tereza KRÁLOVÁ; Lukáš SUKENÍK; S. POKORNÁ; M. HOF a Robert VÁCHA. \textit{Kink in Helical Peptides Affects Membrane Pore Formation}. 2019. ISSN~0006-3495. Dostupné z: https://doi.org/10.1016/j.bpj.2018.11.2760.

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