Ovarian Cancer: Differentially Expressed microRNAs in Tumor
Tissue and Cell-Free Ascitic Fluid as Potential Novel
Biomarkers

J 2019

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

ZAVESKY, Ludek; Eva JANDÁKOVÁ; Vít WEINBERGER; Luboš MINÁŘ; Veronika HANZIKOVA et al.

Základní údaje

Originální název

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

Autoři

ZAVESKY, Ludek; Eva JANDÁKOVÁ; Vít WEINBERGER; Luboš MINÁŘ; Veronika HANZIKOVA; Daniela DUSKOVA; Lenka ZAVESKA DRABKOVA a Ales HORINEK

Vydání

Cancer Investigation, PHILADELPHIA, TAYLOR & FRANCIS, 2019, 0735-7907

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.398

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/19:00112959

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Ovarian cancer; ascites; effusion; microRNA; tumor

Štítky

14110230, 14110411, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2020 11:01, Mgr. Tereza Miškechová

Anotace

V originále

Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.

Citovat

ZAVESKY, Ludek; Eva JANDÁKOVÁ; Vít WEINBERGER; Luboš MINÁŘ; Veronika HANZIKOVA; Daniela DUSKOVA; Lenka ZAVESKA DRABKOVA a Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. Cancer Investigation. PHILADELPHIA: TAYLOR & FRANCIS, 2019, roč. 37, č. 9, s. 440-452. ISSN 0735-7907. Dostupné z: https://doi.org/10.1080/07357907.2019.1663208.

@article{1623056,
   author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Hanzikova, Veronika and Duskova, Daniela and Zaveska Drabkova, Lenka and Horinek, Ales},
   article_location = {PHILADELPHIA},
   article_number = {9},
   doi = {https://doi.org/10.1080/07357907.2019.1663208},
   keywords = {Ovarian cancer; ascites; effusion; microRNA; tumor},
   language = {eng},
   issn = {0735-7907},
   journal = {Cancer Investigation},
   title = {Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers},
   url = {http://dx.doi.org/10.1080/07357907.2019.1663208},
   volume = {37},
   year = {2019}
}

TY  - JOUR
ID  - 1623056
AU  - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Hanzikova, Veronika - Duskova, Daniela - Zaveska Drabkova, Lenka - Horinek, Ales
PY  - 2019
TI  - Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
JF  - Cancer Investigation
VL  - 37
IS  - 9
SP  - 440-452
EP  - 440-452
PB  - TAYLOR & FRANCIS
SN  - 07357907
KW  - Ovarian cancer
KW  - ascites
KW  - effusion
KW  - microRNA
KW  - tumor
UR  - http://dx.doi.org/10.1080/07357907.2019.1663208
L2  - http://dx.doi.org/10.1080/07357907.2019.1663208
N2  - Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
ER  -

ZAVESKY, Ludek; Eva JANDÁKOVÁ; Vít WEINBERGER; Luboš MINÁŘ; Veronika HANZIKOVA; Daniela DUSKOVA; Lenka ZAVESKA DRABKOVA a Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. \textit{Cancer Investigation}. PHILADELPHIA: TAYLOR \&{} FRANCIS, 2019, roč.~37, č.~9, s.~440-452. ISSN~0735-7907. Dostupné z: https://doi.org/10.1080/07357907.2019.1663208.

Přehled o publikaci