Dynamics of tumor-specific cfDNA in response to therapy in
multiple myeloma patients

J 2020

Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients

VRÁBEL, Dávid; Lenka SEDLARIKOVA; Lenka BESSE; Lucie ŘÍHOVÁ; Renata BEZDEKOVA et. al.

Základní údaje

Originální název

Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients

Autoři

Vydání

European Journal of Haematology, Hoboken, Wiley-Blackwell, 2020, 0902-4441

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.997

Kód RIV

RIV/00216224:14110/20:00115336

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/ejh.13358

UT WoS

000503619400001

EID Scopus

2-s2.0-85076894655

Klíčová slova anglicky

cell-free DNA; liquid biopsy; multiple myeloma; qPCR

Štítky

14110518, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 9. 2020 09:20, Mgr. Tereza Miškechová

Anotace

V originále

Objectives Progress in multiple myeloma treatment allows patients to achieve deeper responses, for which the assessment of minimal residual disease (MRD) is critical. Typically, bone marrow samples are used for this purpose; however, this approach is site-limited. Liquid biopsy represents a minimally invasive and more comprehensive technique that is not site-limited, but equally challenging. Methods While majority of current data comes from short-term studies, we present a long-term study on blood-based MRD monitoring using tumor-specific cell-free DNA detection by ASO-qPCR. One hundred and twelve patients were enrolled into the study, but long-term sampling and analysis were feasible only in 45 patients. Results We found a significant correlation of quantity of tumor-specific cell-free DNA levels with clinically meaningful events [induction therapy (P = .004); ASCT (P = .012)]. Moreover, length of cfDNA fragments is associated with better treatment response of patients. Conclusions These results support the concept of tumor-specific cell-free DNA as a prognostic marker.

Návaznosti

MUNI/A/1553/2018, interní kód MU

Název: Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí (Akronym: genetika; stres; biomateriály; tkáňové kultury)

Investor: Masarykova univerzita, Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV17-29343A, projekt VaV

Název: Analýza mikroprostředí kostní dřeně u extramedulárního relapsu mnohočetného myelomu

Citovat

VRÁBEL, Dávid; Lenka SEDLARIKOVA; Lenka BESSE; Lucie ŘÍHOVÁ; Renata BEZDEKOVA; Martina ALMÁŠI; Veronika KUBACZKOVÁ; Lucie BROŽOVÁ; Jiří JARKOVSKÝ; Hana PLONKOVA; Tomas JELINEK; Viera SANDECKA; Martin STORK; Luděk POUR; Sabina ŠEVČÍKOVÁ a Roman HAJEK. Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients. European Journal of Haematology. Hoboken: Wiley-Blackwell, 2020, roč. 104, č. 3, s. 190-197. ISSN 0902-4441. Dostupné z: https://doi.org/10.1111/ejh.13358.

@article{1623778,
   author = {Vrábel, Dávid and Sedlarikova, Lenka and Besse, Lenka and Říhová, Lucie and Bezdekova, Renata and Almáši, Martina and Kubaczková, Veronika and Brožová, Lucie and Jarkovský, Jiří and Plonkova, Hana and Jelinek, Tomas and Sandecka, Viera and Stork, Martin and Pour, Luděk and Ševčíková, Sabina and Hajek, Roman},
   article_location = {Hoboken},
   article_number = {3},
   doi = {https://doi.org/10.1111/ejh.13358},
   keywords = {cell-free DNA; liquid biopsy; multiple myeloma; qPCR},
   language = {eng},
   issn = {0902-4441},
   journal = {European Journal of Haematology},
   title = {Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13358},
   volume = {104},
   year = {2020}
}

TY  - JOUR
ID  - 1623778
AU  - Vrábel, Dávid - Sedlarikova, Lenka - Besse, Lenka - Říhová, Lucie - Bezdekova, Renata - Almáši, Martina - Kubaczková, Veronika - Brožová, Lucie - Jarkovský, Jiří - Plonkova, Hana - Jelinek, Tomas - Sandecka, Viera - Stork, Martin - Pour, Luděk - Ševčíková, Sabina - Hajek, Roman
PY  - 2020
TI  - Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients
JF  - European Journal of Haematology
VL  - 104
IS  - 3
SP  - 190-197
EP  - 190-197
PB  - Wiley-Blackwell
SN  - 09024441
KW  - cell-free DNA
KW  - liquid biopsy
KW  - multiple myeloma
KW  - qPCR
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13358
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13358
N2  - Objectives Progress in multiple myeloma treatment allows patients to achieve deeper responses, for which the assessment of minimal residual disease (MRD) is critical. Typically, bone marrow samples are used for this purpose; however, this approach is site-limited. Liquid biopsy represents a minimally invasive and more comprehensive technique that is not site-limited, but equally challenging. Methods While majority of current data comes from short-term studies, we present a long-term study on blood-based MRD monitoring using tumor-specific cell-free DNA detection by ASO-qPCR. One hundred and twelve patients were enrolled into the study, but long-term sampling and analysis were feasible only in 45 patients. Results We found a significant correlation of quantity of tumor-specific cell-free DNA levels with clinically meaningful events [induction therapy (P = .004); ASCT (P = .012)]. Moreover, length of cfDNA fragments is associated with better treatment response of patients. Conclusions These results support the concept of tumor-specific cell-free DNA as a prognostic marker.
ER  -

VRÁBEL, Dávid; Lenka SEDLARIKOVA; Lenka BESSE; Lucie ŘÍHOVÁ; Renata BEZDEKOVA; Martina ALMÁŠI; Veronika KUBACZKOVÁ; Lucie BROŽOVÁ; Jiří JARKOVSKÝ; Hana PLONKOVA; Tomas JELINEK; Viera SANDECKA; Martin STORK; Luděk POUR; Sabina ŠEVČÍKOVÁ a Roman HAJEK. Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients. \textit{European Journal of Haematology}. Hoboken: Wiley-Blackwell, 2020, roč.~104, č.~3, s.~190-197. ISSN~0902-4441. Dostupné z: https://doi.org/10.1111/ejh.13358.

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