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@article{1624676,
author = {BorysandWojcik, S. and Brazert, S. and Jankowski, M. and Ozegowska, M. and Chermula, K. and PiotrowskaandKempisty, B. and Bukowska, H. and Antosik, D. and Pawelczyk, P. and Nowicki, L. and Ješeta, Michal and Kempisty, M.},
article_location = {Silva Marina},
article_number = {1},
keywords = {mesenchymal stem cells; WJ; properties; isolation; clinical application},
language = {eng},
issn = {0393-974X},
journal = {Journal of biological regulators and homeostatic agents},
title = {HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS},
url = {https://www.ncbi.nlm.nih.gov/pubmed/30729769},
volume = {33},
year = {2019}
}
TY - JOUR
ID - 1624676
AU - Borys-Wojcik, S. - Brazert, S. - Jankowski, M. - Ozegowska, M. - Chermula, K. - Piotrowska-Kempisty, B. - Bukowska, H. - Antosik, D. - Pawelczyk, P. - Nowicki, L. - Ješeta, Michal - Kempisty, M.
PY - 2019
TI - HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS
JF - Journal of biological regulators and homeostatic agents
VL - 33
IS - 1
SP - 119-123
EP - 119-123
PB - Biolife SAS
SN - 0393974X
KW - mesenchymal stem cells
KW - WJ
KW - properties
KW - isolation
KW - clinical application
UR - https://www.ncbi.nlm.nih.gov/pubmed/30729769
L2 - https://www.ncbi.nlm.nih.gov/pubmed/30729769
N2 - Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.
ER -
BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA, B. PIOTROWSKA-KEMPISTY, H. BUKOWSKA, D. ANTOSIK, P. PAWELCZYK, L. NOWICKI, Michal JEŠETA a M. KEMPISTY. HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS. \textit{Journal of biological regulators and homeostatic agents}. Silva Marina: Biolife SAS, 2019, roč.~33, č.~1, s.~119-123. ISSN~0393-974X.
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