HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES,
ISOLATION AND CLINICAL APPLICATIONS

J 2019

HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS

BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA et. al.

Základní údaje

Originální název

HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS

Autoři

BORYS-WOJCIK, S. (616 Polsko), S. BRAZERT (616 Polsko), M. JANKOWSKI (616 Polsko), M. OZEGOWSKA (616 Polsko), K. CHERMULA (616 Polsko), B. PIOTROWSKA-KEMPISTY (616 Polsko), H. BUKOWSKA (616 Polsko), D. ANTOSIK (616 Polsko), P. PAWELCZYK (616 Polsko), L. NOWICKI (616 Polsko), Michal JEŠETA (203 Česká republika, domácí) a M. KEMPISTY (616 Polsko, garant)

Vydání

Journal of biological regulators and homeostatic agents, Silva Marina, Biolife SAS, 2019, 0393-974X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.506

Kód RIV

RIV/00216224:14110/19:00113003

Organizační jednotka

Lékařská fakulta

UT WoS

000464697500015

Klíčová slova anglicky

mesenchymal stem cells; WJ; properties; isolation; clinical application

Štítky

14110411, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 4. 2020 14:25, Mgr. Tereza Miškechová

Anotace

V originále

Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.

Citovat

BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA, B. PIOTROWSKA-KEMPISTY, H. BUKOWSKA, D. ANTOSIK, P. PAWELCZYK, L. NOWICKI, Michal JEŠETA a M. KEMPISTY. HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS. Journal of biological regulators and homeostatic agents. Silva Marina: Biolife SAS, 2019, roč. 33, č. 1, s. 119-123. ISSN 0393-974X.

@article{1624676,
   author = {BorysandWojcik, S. and Brazert, S. and Jankowski, M. and Ozegowska, M. and Chermula, K. and PiotrowskaandKempisty, B. and Bukowska, H. and Antosik, D. and Pawelczyk, P. and Nowicki, L. and Ješeta, Michal and Kempisty, M.},
   article_location = {Silva Marina},
   article_number = {1},
   keywords = {mesenchymal stem cells; WJ; properties; isolation; clinical application},
   language = {eng},
   issn = {0393-974X},
   journal = {Journal of biological regulators and homeostatic agents},
   title = {HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/30729769},
   volume = {33},
   year = {2019}
}

TY  - JOUR
ID  - 1624676
AU  - Borys-Wojcik, S. - Brazert, S. - Jankowski, M. - Ozegowska, M. - Chermula, K. - Piotrowska-Kempisty, B. - Bukowska, H. - Antosik, D. - Pawelczyk, P. - Nowicki, L. - Ješeta, Michal - Kempisty, M.
PY  - 2019
TI  - HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS
JF  - Journal of biological regulators and homeostatic agents
VL  - 33
IS  - 1
SP  - 119-123
EP  - 119-123
PB  - Biolife SAS
SN  - 0393974X
KW  - mesenchymal stem cells
KW  - WJ
KW  - properties
KW  - isolation
KW  - clinical application
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30729769
L2  - https://www.ncbi.nlm.nih.gov/pubmed/30729769
N2  - Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.
ER  -

BORYS-WOJCIK, S., S. BRAZERT, M. JANKOWSKI, M. OZEGOWSKA, K. CHERMULA, B. PIOTROWSKA-KEMPISTY, H. BUKOWSKA, D. ANTOSIK, P. PAWELCZYK, L. NOWICKI, Michal JEŠETA a M. KEMPISTY. HUMAN WHARTON'S JELLY MESENCHYMAL STEM CELLS: PROPERTIES, ISOLATION AND CLINICAL APPLICATIONS. \textit{Journal of biological regulators and homeostatic agents}. Silva Marina: Biolife SAS, 2019, roč.~33, č.~1, s.~119-123. ISSN~0393-974X.

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