2019
Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA
BENESOVA, Lucie; Tereza HALKOVA; Renata PTACKOVA; Anastasiya SEMYAKINA; Katerina MENCLOVA et al.Základní údaje
Originální název
Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA
Autoři
BENESOVA, Lucie; Tereza HALKOVA; Renata PTACKOVA; Anastasiya SEMYAKINA; Katerina MENCLOVA; Jiri PUDIL; Miroslav RYSKA; Miroslav LEVY; Jaromir SIMSA; Filip PAZDIREK; Jiri HOCH; Milan BLAHA a Marek MINARIK
Vydání
World Journal of Gastroenterology, Baishideng, 2019, 1007-9327
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30219 Gastroenterology and hepatology
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 3.665
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/19:00108601
Organizační jednotka
Lékařská fakulta
UT WoS
EID Scopus
Klíčová slova anglicky
Circulating tumor DNA; Metastatic colorectal cancer; Postoperative; Radicality of resection; Follow-up; Recurrence
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 2. 2020 10:37, Mgr. Tereza Miškechová
Anotace
V originále
BACKGROUND One of the most notable applications for circulating tumor DNA (ctDNA) detection in peripheral blood of patients with metastatic colorectal cancer (mCRC) is a long-term postoperative follow-up. Sometimes referred to as a "liquid (re)biopsy" it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals (months or even weeks). The presence of the disease and the actual extent of the tumor burden (tumor mass) within the patient's body can be monitored. This is of particular importance, especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence. AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer. METHODS A total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers. Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling. In addition to the baseline ctDNA testing prior to surgery, a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals. The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient. RESULTS Among the monitored patients, the R0 (curative) resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures (26/28, 93%). In the remaining cases of R0 surgeries that displayed ctDNA, both patients were diagnosed with a recurrence of the disease after 6 months. In 7 patients who underwent an R1 resection, 4 ctDNA positivities (4/7, 57%) were detected after surgery and associated with the confirmation of early disease recurrence (after 3 to 7 months). All 15 patients (15/15, 100%) undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period. In 22 cases of recurrence, ctDNA positivity was detected 22 times (22/22, 100%) compared to 16 positives (16/22, 73%) by imaging methods and 15 cases (15/22, 68%) of elevated tumor markers. CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.
Návaznosti
| NV15-27939A, projekt VaV |
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