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@article{1633037,
author = {Čupera, Jakub and Lánský, Petr},
article_location = {London},
article_number = {10},
doi = {http://dx.doi.org/10.3109/03639045.2012.719907},
keywords = {Dissolution; Fisher information; rate constant; optimal sampling times},
language = {eng},
issn = {0363-9045},
journal = {DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY},
title = {On the estimate of the rate constant in the homogeneous dissolution model},
url = {https://www.tandfonline.com/doi/abs/10.3109/03639045.2012.719907?journalCode=iddi20},
volume = {39},
year = {2013}
}
TY - JOUR
ID - 1633037
AU - Čupera, Jakub - Lánský, Petr
PY - 2013
TI - On the estimate of the rate constant in the homogeneous dissolution model
JF - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
VL - 39
IS - 10
SP - 1555-1561
EP - 1555-1561
PB - Dekker
SN - 03639045
KW - Dissolution
KW - Fisher information
KW - rate constant
KW - optimal sampling times
UR - https://www.tandfonline.com/doi/abs/10.3109/03639045.2012.719907?journalCode=iddi20
L2 - https://www.tandfonline.com/doi/abs/10.3109/03639045.2012.719907?journalCode=iddi20
N2 - The aim is to determine how well the rate parameter of the homogeneous model of dissolution can be estimated in dependency on the chosen times to measure the empirical data. The approach is based on the theory of Fisher information. We show that if the probability distribution of the measurement errors is known, the data should be collected at a single time instant or its close proximity in order to obtain the best estimate. This is in sharp contrast with commonly used experimental protocols. Further, from the properties of the Fisher information we deduce how suitable is the model of measurement error and we show that asymmetric distribution of data close to the time origin is unavoidable.
ER -
ČUPERA, Jakub a Petr LÁNSKÝ. On the estimate of the rate constant in the homogeneous dissolution model. \textit{DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY}. London: Dekker, 2013, roč.~39, č.~10, s.~1555-1561. ISSN~0363-9045. Dostupné z: https://dx.doi.org/10.3109/03639045.2012.719907.
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