Impairment of brain functions in Parkinson's disease reflected
by alterations in neural connectivity in EEG studies: A
viewpoint

J 2019

Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

BOČKOVÁ, Martina and Ivan REKTOR

Basic information

Original name

Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

Authors

BOČKOVÁ, Martina (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Clinical Neurophysiology, Clare, Elsevier Ireland, 2019, 1388-2457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.214

RIV identification code

RIV/00216224:14740/19:00108608

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.clinph.2018.11.013

UT WoS

000456164600006

Keywords in English

Parkinson's disease; EEG; Local field potentials; Functional connectivity; Graph theory; Deep brain stimulation

Abstract

V originále

Clinical symptoms of Parkinson's disease (PD) are accompanied by pathological phenomena detected locally in the basal ganglia (BG) as changes in local field potentials (LFPs) and also in cortical regions by electroencephalography (EEG). The literature published mainly between 2000 and 2017 was reviewed with an emphasis on approaches emerging after 2000, in particular on oscillatory dynamics, connectivity studies, and deep brain stimulation. Eighty-five articles were reviewed. The main observations were a general slowing of background activity, excessive synchronization of beta activity, and disturbed movement-related gamma oscillations in the BG and in the cortico-subcortical and cortico-cortical motor loops, suppressible by dopaminergic medication as well as by high-frequency deep brain stimulation (DBS). Non-motor symptoms are related mainly to changes in the alpha frequency range. EEG parameters can be useful in defining the risk of dementia in PD. Further progress was reported recently using advanced analytical technologies and high-performance computing (graph theory). Detailed knowledge of LFPs in PD enabled progress particularly in DBS therapy, which requires optimizing the clinical effect and minimizing adverse side effects. The neurocognitive networks and their dysfunction in PD and DBS therapy are promising targets for future research. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.

Links

NV16-33798A, research and development project

Name: Modulace funkční konektivity kortikálních sítí vlivem STN DBS

Citovat

BOČKOVÁ, Martina and Ivan REKTOR. Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint. Clinical Neurophysiology. Clare: Elsevier Ireland, 2019, vol. 130, No 2, p. 239-247. ISSN 1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2018.11.013.

@article{1636617,
   author = {Bočková, Martina and Rektor, Ivan},
   article_location = {Clare},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.clinph.2018.11.013},
   keywords = {Parkinson's disease; EEG; Local field potentials; Functional connectivity; Graph theory; Deep brain stimulation},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint},
   url = {https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub#!},
   volume = {130},
   year = {2019}
}

TY  - JOUR
ID  - 1636617
AU  - Bočková, Martina - Rektor, Ivan
PY  - 2019
TI  - Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint
JF  - Clinical Neurophysiology
VL  - 130
IS  - 2
SP  - 239-247
EP  - 239-247
PB  - Elsevier Ireland
SN  - 13882457
KW  - Parkinson's disease
KW  - EEG
KW  - Local field potentials
KW  - Functional connectivity
KW  - Graph theory
KW  - Deep brain stimulation
UR  - https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub#!
L2  - https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub#!
N2  - Clinical symptoms of Parkinson's disease (PD) are accompanied by pathological phenomena detected locally in the basal ganglia (BG) as changes in local field potentials (LFPs) and also in cortical regions by electroencephalography (EEG). The literature published mainly between 2000 and 2017 was reviewed with an emphasis on approaches emerging after 2000, in particular on oscillatory dynamics, connectivity studies, and deep brain stimulation. Eighty-five articles were reviewed. The main observations were a general slowing of background activity, excessive synchronization of beta activity, and disturbed movement-related gamma oscillations in the BG and in the cortico-subcortical and cortico-cortical motor loops, suppressible by dopaminergic medication as well as by high-frequency deep brain stimulation (DBS). Non-motor symptoms are related mainly to changes in the alpha frequency range. EEG parameters can be useful in defining the risk of dementia in PD. Further progress was reported recently using advanced analytical technologies and high-performance computing (graph theory). Detailed knowledge of LFPs in PD enabled progress particularly in DBS therapy, which requires optimizing the clinical effect and minimizing adverse side effects. The neurocognitive networks and their dysfunction in PD and DBS therapy are promising targets for future research. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.
ER  -

BOČKOVÁ, Martina and Ivan REKTOR. Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint. \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, 2019, vol.~130, No~2, p.~239-247. ISSN~1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2018.11.013.

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