Altered Resting State Functional Activity and Microstructure of
the White Matter in Migraine With Aura

J 2019

Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura

FARAGÓ, Péter, E. TOTH, K. KOCSIS, B. KINCSES, D. VEREB et. al.

Basic information

Original name

Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura

Authors

FARAGÓ, Péter (348 Hungary, belonging to the institution), E. TOTH, K. KOCSIS, B. KINCSES, D. VEREB, András KIRÁLY (348 Hungary, belonging to the institution), B. BOZSIK, J. TAJTI, A. PARDUTZ, D. SZOK, L. VECSEI, Nikoletta SZABÓ (348 Hungary, belonging to the institution) and Z.T. KINCSES

Edition

FRONTIERS IN NEUROLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2019, 1664-2295

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.889

RIV identification code

RIV/00216224:14740/19:00113375

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3389/fneur.2019.01039

UT WoS

000497554400001

Keywords in English

migraine; resting state; fMRI; white matter; diffusion; ALFF

Abstract

V originále

Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Resting fluctuation of the BOLD signal in the white matter was reported recently. The question arising whether the white matter activity, that is strongly coupled with gray matter activity is also perturbed differentially in the two subtypes of the disease and if so, is it related to the microstructural alterations of the white matter. Methods: Resting state fMRI, 60 directional DTI images and high-resolution T1 images were obtained from 51 migraine patients and 32 healthy volunteers. The images were pre-processed and the white matter was extracted. Independent component analysis was performed to obtain white matter functional networks. The differential expression of the white matter functional networks in the two subtypes of the disease was investigated with dual-regression approach. The Fourier spectrum of the resting fMRI fluctuations were compared between groups. Voxel-wise correlation was calculated between the resting state functional activity fluctuations and white matter microstructural measures. Results: Three white matter networks were identified that were expressed differently in migraine with and without aura. Migraineurs with aura showed increased functional connectivity and amplitude of BOLD fluctuation. Fractional anisotropy and radial diffusivity showed strong correlation with the expression of the frontal white matter network in patients with aura. Discussion: Our study is the first to describe changes in white matter resting state functional activity in migraine with aura, showing correlation with the underlying microstructure. Functional and structural differences between disease subtypes suggest at least partially different pathomechanism, which may necessitate handling of these subtypes as separate entities in further studies.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

FARAGÓ, Péter, E. TOTH, K. KOCSIS, B. KINCSES, D. VEREB, András KIRÁLY, B. BOZSIK, J. TAJTI, A. PARDUTZ, D. SZOK, L. VECSEI, Nikoletta SZABÓ and Z.T. KINCSES. Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura. FRONTIERS IN NEUROLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2019, vol. 10, OCT, p. 1-8. ISSN 1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2019.01039.

@article{1639822,
   author = {Faragó, Péter and Toth, E. and Kocsis, K. and Kincses, B. and Vereb, D. and Király, András and Bozsik, B. and Tajti, J. and Pardutz, A. and Szok, D. and Vecsei, L. and Szabó, Nikoletta and Kincses, Z.T.},
   article_location = {LAUSANNE},
   article_number = {OCT},
   doi = {http://dx.doi.org/10.3389/fneur.2019.01039},
   keywords = {migraine; resting state; fMRI; white matter; diffusion; ALFF},
   language = {eng},
   issn = {1664-2295},
   journal = {FRONTIERS IN NEUROLOGY},
   title = {Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura},
   url = {https://www.frontiersin.org/articles/10.3389/fneur.2019.01039/full},
   volume = {10},
   year = {2019}
}

TY  - JOUR
ID  - 1639822
AU  - Faragó, Péter - Toth, E. - Kocsis, K. - Kincses, B. - Vereb, D. - Király, András - Bozsik, B. - Tajti, J. - Pardutz, A. - Szok, D. - Vecsei, L. - Szabó, Nikoletta - Kincses, Z.T.
PY  - 2019
TI  - Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura
JF  - FRONTIERS IN NEUROLOGY
VL  - 10
IS  - OCT
SP  - 1-8
EP  - 1-8
PB  - FRONTIERS MEDIA SA
SN  - 16642295
KW  - migraine
KW  - resting state
KW  - fMRI
KW  - white matter
KW  - diffusion
KW  - ALFF
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2019.01039/full
L2  - https://www.frontiersin.org/articles/10.3389/fneur.2019.01039/full
N2  - Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Resting fluctuation of the BOLD signal in the white matter was reported recently. The question arising whether the white matter activity, that is strongly coupled with gray matter activity is also perturbed differentially in the two subtypes of the disease and if so, is it related to the microstructural alterations of the white matter. Methods: Resting state fMRI, 60 directional DTI images and high-resolution T1 images were obtained from 51 migraine patients and 32 healthy volunteers. The images were pre-processed and the white matter was extracted. Independent component analysis was performed to obtain white matter functional networks. The differential expression of the white matter functional networks in the two subtypes of the disease was investigated with dual-regression approach. The Fourier spectrum of the resting fMRI fluctuations were compared between groups. Voxel-wise correlation was calculated between the resting state functional activity fluctuations and white matter microstructural measures. Results: Three white matter networks were identified that were expressed differently in migraine with and without aura. Migraineurs with aura showed increased functional connectivity and amplitude of BOLD fluctuation. Fractional anisotropy and radial diffusivity showed strong correlation with the expression of the frontal white matter network in patients with aura. Discussion: Our study is the first to describe changes in white matter resting state functional activity in migraine with aura, showing correlation with the underlying microstructure. Functional and structural differences between disease subtypes suggest at least partially different pathomechanism, which may necessitate handling of these subtypes as separate entities in further studies.
ER  -

FARAGÓ, Péter, E. TOTH, K. KOCSIS, B. KINCSES, D. VEREB, András KIRÁLY, B. BOZSIK, J. TAJTI, A. PARDUTZ, D. SZOK, L. VECSEI, Nikoletta SZABÓ and Z.T. KINCSES. Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura. \textit{FRONTIERS IN NEUROLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2019, vol.~10, OCT, p.~1-8. ISSN~1664-2295. Available from: https://dx.doi.org/10.3389/fneur.2019.01039.

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