| DESIMONE, G., E.M.C. MAZZA, A. CASSOTTA, Alexey Nikolayevich DAVYDOV, A.N. KUKA, M. ZANON, V. DE PAOLI, F. SCAMARDELLA, Maria METSGER, M. ROBERTO, A. PILIPOW, K. COLOMBO, F.S. TENEDINI, E. TAGLIAFICO, E. GATTINONI, L. MAVILIO, D. PEANO, C. PRICE, D.A. SINGH, S.P. FARBER, J.M. SERRA, V. CUCCA, F. FERRARI, F. ORRU, V. FIORILLO, E. IANNACONE, Dmitriy CHUDAKOV, D.M. SALLUSTO a F. LUGLI. CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential. Journal of immunology. Bethesda: American association of immunologists, 2019, roč. 203, č. 12, s. 3179-3189. ISSN 0022-1767. Dostupné z: https://dx.doi.org/10.4049/jimmunol.1901072. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1639824,
author = {DeSimone, G. and Mazza, E.M.C. and Cassotta, A. and Davydov, Alexey Nikolayevich and Kuka, A.N. and Zanon, M. and De Paoli, V. and Scamardella, F. and Metsger, Maria and Roberto, M. and Pilipow, A. and Colombo, K. and Tenedini, F.S. and Tagliafico, E. and Gattinoni, E. and Mavilio, L. and Peano, D. and Price, C. and Singh, D.A. and Farber, S.P. and Serra, J.M. and Cucca, V. and Ferrari, F. and Orru, F. and Fiorillo, V. and Iannacone, E. and Chudakov, Dmitriy and Sallusto, D.M. and Lugli, F.},
article_location = {Bethesda},
article_number = {12},
doi = {http://dx.doi.org/10.4049/jimmunol.1901072},
keywords = {RECEPTOR EXPRESSION; FLOW-CYTOMETRY; CENTRAL MEMORY; CD4(+); REPERTOIRE; PHENOTYPE; EXPANSION; RECONSTITUTION; POPULATIONS; DIVERSITY},
language = {eng},
issn = {0022-1767},
journal = {Journal of immunology},
title = {CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential},
url = {https://www.jimmunol.org/content/203/12/3179},
volume = {203},
year = {2019}
}
TY - JOUR
ID - 1639824
AU - DeSimone, G. - Mazza, E.M.C. - Cassotta, A. - Davydov, Alexey Nikolayevich - Kuka, A.N. - Zanon, M. - De Paoli, V. - Scamardella, F. - Metsger, Maria - Roberto, M. - Pilipow, A. - Colombo, K. - Tenedini, F.S. - Tagliafico, E. - Gattinoni, E. - Mavilio, L. - Peano, D. - Price, C. - Singh, D.A. - Farber, S.P. - Serra, J.M. - Cucca, V. - Ferrari, F. - Orru, F. - Fiorillo, V. - Iannacone, E. - Chudakov, Dmitriy - Sallusto, D.M. - Lugli, F.
PY - 2019
TI - CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential
JF - Journal of immunology
VL - 203
IS - 12
SP - 3179-3189
EP - 3179-3189
PB - American association of immunologists
SN - 00221767
KW - RECEPTOR EXPRESSION
KW - FLOW-CYTOMETRY
KW - CENTRAL MEMORY
KW - CD4(+)
KW - REPERTOIRE
KW - PHENOTYPE
KW - EXPANSION
KW - RECONSTITUTION
KW - POPULATIONS
KW - DIVERSITY
UR - https://www.jimmunol.org/content/203/12/3179
L2 - https://www.jimmunol.org/content/203/12/3179
N2 - In mice, the ability of naive T (T-N) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8(+) T-N cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3(+) T-N cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide-HLA class I Ags. Moreover, CXCR3(+) T-N cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3(+) T-N cells were transcriptionally equivalent to murine CXCR3(+) T-N cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8(+) T cells.
ER -
DESIMONE, G., E.M.C. MAZZA, A. CASSOTTA, Alexey Nikolayevich DAVYDOV, A.N. KUKA, M. ZANON, V. DE PAOLI, F. SCAMARDELLA, Maria METSGER, M. ROBERTO, A. PILIPOW, K. COLOMBO, F.S. TENEDINI, E. TAGLIAFICO, E. GATTINONI, L. MAVILIO, D. PEANO, C. PRICE, D.A. SINGH, S.P. FARBER, J.M. SERRA, V. CUCCA, F. FERRARI, F. ORRU, V. FIORILLO, E. IANNACONE, Dmitriy CHUDAKOV, D.M. SALLUSTO a F. LUGLI. CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential. \textit{Journal of immunology}. Bethesda: American association of immunologists, 2019, roč.~203, č.~12, s.~3179-3189. ISSN~0022-1767. Dostupné z: https://dx.doi.org/10.4049/jimmunol.1901072.
|
