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@article{1639996,
author = {Mach, Samuel and Jegorov, A. and Kuzma, M. and Zapal, J. and Šimek, Zdeněk and Cejka, J. and Eigner, V.},
article_location = {Heidelberg},
article_number = {34},
doi = {http://dx.doi.org/10.1007/s11356-019-06568-y},
keywords = {Abiraterone acetate; Metabolites; Fish; Epoxidation; Ameiurus nebulosus; HPLC; MS; NMR},
language = {eng},
issn = {0944-1344},
journal = {Environmental Science and Pollution Research},
title = {Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)},
url = {http://dx.doi.org/10.1007/s11356-019-06568-y},
volume = {26},
year = {2019}
}
TY - JOUR
ID - 1639996
AU - Mach, Samuel - Jegorov, A. - Kuzma, M. - Zapal, J. - Šimek, Zdeněk - Cejka, J. - Eigner, V.
PY - 2019
TI - Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)
JF - Environmental Science and Pollution Research
VL - 26
IS - 34
SP - 34896-34904
EP - 34896-34904
PB - Springer Heidelberg
SN - 09441344
KW - Abiraterone acetate
KW - Metabolites
KW - Fish
KW - Epoxidation
KW - Ameiurus nebulosus
KW - HPLC
KW - MS
KW - NMR
UR - http://dx.doi.org/10.1007/s11356-019-06568-y
L2 - http://dx.doi.org/10.1007/s11356-019-06568-y
N2 - Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary (products of glucuronidation and sulfatation) metabolites of abiraterone acetate were identified. The NMR measurement of one of the prevailing metabolites presumed to be one of possible hydroxy-abiraterones discovered that it is not hydroxy-abiraterone but abiraterone 16,17-epoxide. Closer analysis of MS2 and MS3 spectra revealed that one of presumed hydroxy-abiraterone acetates and also some secondary metabolites are probably 16,17-epoxides.
ER -
MACH, Samuel, A. JEGOROV, M. KUZMA, J. ZAPAL, Zdeněk ŠIMEK, J. CEJKA a V. EIGNER. Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus). \textit{Environmental Science and Pollution Research}. Heidelberg: Springer Heidelberg, 2019, roč.~26, č.~34, s.~34896-34904. ISSN~0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-019-06568-y.
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