Electrochemically prepared composites of graphene oxide and
conducting polymers: Cytocompatibility of cardiomyocytes and
neural progenitors

J 2019

Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors

MARAKOVA, Nela; Zhanna A. BOEVA; Petr HUMPOLÍČEK; Tom LINDFORS; Jiří PACHERNÍK et al.

Základní údaje

Originální název

Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors

Autoři

MARAKOVA, Nela; Zhanna A. BOEVA; Petr HUMPOLÍČEK; Tom LINDFORS; Jiří PACHERNÍK; Vera KASPARKOVA; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPAKOVA; Antonin MINARIK a Marian LEHOCKY

Vydání

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, AMSTERDAM, ELSEVIER SCIENCE BV, 2019, 0928-4931

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20501 Materials engineering

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.880

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/19:00108220

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Composites; Graphene oxide; Polypyrrole; PEDOT; Cardiomyocytes; Neural progenitors

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 4. 2020 10:42, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The cytocompatibility of cardiomyocytes derived from embryonic stem cells and neural progenitors, which were seeded on the surface of composite films made of graphene oxide (GO) and polypyrrole (PPy-GO) or poly(3,4-ethylenedioxythiophene) (PEDOT-GO) are reported. The GO incorporated in the composite matrix contributes to the patterning of the composite surface, while the electrically conducting PPy and PEDOT serve as ion-to-electron transducers facilitating electrical stimulation/sensing. The films were fabricated by a simple one-step electropolymerization procedure on electrically conducting indium tin oxide (ITO) and graphene paper (GP) substrates. Factors affecting the cell behaviour, i.e. the surface topography, wettability, and electrical surface conductivity, were studied. The PPy-GO and PEDOT-GO prepared on ITO exhibited high surface conductivity, especially in the case of the ITO/PPy-GO composite. We found that for cardiomyocytes, the PPy-GO and PEDOT-GO composites counteracted the negative effect of the GP substrate that inhibited their growth. Both the PPy-GO and PEDOT-GO composites prepared on ITO and GP significantly decreased the cytocompatibility of neural progenitors. The presented results enhance the knowledge about the biological properties of electroactive materials, which are critical for tissue engineering, especially in context stimuli-responsive scaffolds.

Návaznosti

GA19-16861S, projekt VaV

Název: Interakce biomateriálů s kmenovými buňkami v simulovaných in vivo podmínkách (Akronym: IBMSKB)

Investor: Grantová agentura ČR, Interakce biomateriálů s kmenovými buňkami v simulovaných in vivo podmínkách

Citovat

MARAKOVA, Nela; Zhanna A. BOEVA; Petr HUMPOLÍČEK; Tom LINDFORS; Jiří PACHERNÍK; Vera KASPARKOVA; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPAKOVA; Antonin MINARIK a Marian LEHOCKY. Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, roč. 105, DEC 2019, s. 1-10. ISSN 0928-4931. Dostupné z: https://doi.org/10.1016/j.msec.2019.110029.

@article{1641479,
   author = {Marakova, Nela and Boeva, Zhanna A. and Humpolíček, Petr and Lindfors, Tom and Pacherník, Jiří and Kasparkova, Vera and Radaszkiewicz, Katarzyna Anna and Capakova, Zdenka and Minarik, Antonin and Lehocky, Marian},
   article_location = {AMSTERDAM},
   article_number = {DEC 2019},
   doi = {https://doi.org/10.1016/j.msec.2019.110029},
   keywords = {Composites; Graphene oxide; Polypyrrole; PEDOT; Cardiomyocytes; Neural progenitors},
   language = {eng},
   issn = {0928-4931},
   journal = {MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS},
   title = {Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors},
   url = {https://www.sciencedirect.com/science/article/pii/S0928493119321563},
   volume = {105},
   year = {2019}
}

TY  - JOUR
ID  - 1641479
AU  - Marakova, Nela - Boeva, Zhanna A. - Humpolíček, Petr - Lindfors, Tom - Pacherník, Jiří - Kasparkova, Vera - Radaszkiewicz, Katarzyna Anna - Capakova, Zdenka - Minarik, Antonin - Lehocky, Marian
PY  - 2019
TI  - Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors
JF  - MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
VL  - 105
IS  - DEC 2019
SP  - 1-10
EP  - 1-10
PB  - ELSEVIER SCIENCE BV
SN  - 09284931
KW  - Composites
KW  - Graphene oxide
KW  - Polypyrrole
KW  - PEDOT
KW  - Cardiomyocytes
KW  - Neural progenitors
UR  - https://www.sciencedirect.com/science/article/pii/S0928493119321563
L2  - https://www.sciencedirect.com/science/article/pii/S0928493119321563
N2  - The cytocompatibility of cardiomyocytes derived from embryonic stem cells and neural progenitors, which were seeded on the surface of composite films made of graphene oxide (GO) and polypyrrole (PPy-GO) or poly(3,4-ethylenedioxythiophene) (PEDOT-GO) are reported. The GO incorporated in the composite matrix contributes to the patterning of the composite surface, while the electrically conducting PPy and PEDOT serve as ion-to-electron transducers facilitating electrical stimulation/sensing. The films were fabricated by a simple one-step electropolymerization procedure on electrically conducting indium tin oxide (ITO) and graphene paper (GP) substrates. Factors affecting the cell behaviour, i.e. the surface topography, wettability, and electrical surface conductivity, were studied. The PPy-GO and PEDOT-GO prepared on ITO exhibited high surface conductivity, especially in the case of the ITO/PPy-GO composite. We found that for cardiomyocytes, the PPy-GO and PEDOT-GO composites counteracted the negative effect of the GP substrate that inhibited their growth. Both the PPy-GO and PEDOT-GO composites prepared on ITO and GP significantly decreased the cytocompatibility of neural progenitors. The presented results enhance the knowledge about the biological properties of electroactive materials, which are critical for tissue engineering, especially in context stimuli-responsive scaffolds.
ER  -

MARAKOVA, Nela; Zhanna A. BOEVA; Petr HUMPOLÍČEK; Tom LINDFORS; Jiří PACHERNÍK; Vera KASPARKOVA; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPAKOVA; Antonin MINARIK a Marian LEHOCKY. Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors. \textit{MATERIALS SCIENCE \&{}amp; ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS}. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, roč.~105, DEC 2019, s.~1-10. ISSN~0928-4931. Dostupné z: https://doi.org/10.1016/j.msec.2019.110029.

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