Biodegradable free-standing films from lauroyl derivatives of
hyaluronan

J 2019

Biodegradable free-standing films from lauroyl derivatives of hyaluronan

CHMELAR, J.; J. MRAZEK; M. HERMANNOVA; L. KUBALA; G. AMBROZOVA et al.

Základní údaje

Originální název

Biodegradable free-standing films from lauroyl derivatives of hyaluronan

Autoři

CHMELAR, J.; J. MRAZEK; M. HERMANNOVA; L. KUBALA; G. AMBROZOVA; Anna KOCURKOVÁ; T. DRMOTA; K. NESPOROVA; L. GRUSOVA a V. VELEBNY

Vydání

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2019, 0144-8617

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.182

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/19:00113440

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Lauroyl hyaluronan; Film; Solution casting; Swelling; Enzymatic degradation; In-vivo evaluation

Štítky

rivok

Změněno: 1. 4. 2020 11:07, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Hyaluronan (HA) films exhibit properties suitable for medical applications, but the solubility of HA limits their use in aqueous environments. This can be overcome by modifying HA with hydrophobic side groups that enable physical cross-linking. In this work, we present water insoluble free-standing films from lauroyl modified HA as novel biomaterials with properties tuneable by the degree of HA substitution. The films are homogeneous, mechanically strong, and flexible and can be sterilized by ethylenoxide. To characterize the films, we measured their thickness, dry mass, content of residual organic solvent, mechanical properties, swelling and enzymatic degradation. The safety and biodegradability of the films were tested both in-vitro and in-vivo, showing that the films are safe and that their degradation can be tailored by the degree of HA substitution.

Citovat

CHMELAR, J.; J. MRAZEK; M. HERMANNOVA; L. KUBALA; G. AMBROZOVA; Anna KOCURKOVÁ; T. DRMOTA; K. NESPOROVA; L. GRUSOVA a V. VELEBNY. Biodegradable free-standing films from lauroyl derivatives of hyaluronan. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2019, roč. 224, NOV 15 2019, s. 1-7. ISSN 0144-8617. Dostupné z: https://doi.org/10.1016/j.carbpol.2019.115162.

@article{1641497,
   author = {Chmelar, J. and Mrazek, J. and Hermannova, M. and Kubala, L. and Ambrozova, G. and Kocurková, Anna and Drmota, T. and Nesporova, K. and Grusova, L. and Velebny, V.},
   article_location = {Oxford},
   article_number = {NOV 15 2019},
   doi = {https://doi.org/10.1016/j.carbpol.2019.115162},
   keywords = {Lauroyl hyaluronan; Film; Solution casting; Swelling; Enzymatic degradation; In-vivo evaluation},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Biodegradable free-standing films from lauroyl derivatives of hyaluronan},
   url = {https://www.sciencedirect.com/science/article/pii/S014486171930829X},
   volume = {224},
   year = {2019}
}

TY  - JOUR
ID  - 1641497
AU  - Chmelar, J. - Mrazek, J. - Hermannova, M. - Kubala, L. - Ambrozova, G. - Kocurková, Anna - Drmota, T. - Nesporova, K. - Grusova, L. - Velebny, V.
PY  - 2019
TI  - Biodegradable free-standing films from lauroyl derivatives of hyaluronan
JF  - Carbohydrate Polymers
VL  - 224
IS  - NOV 15 2019
SP  - 1-7
EP  - 1-7
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Lauroyl hyaluronan
KW  - Film
KW  - Solution casting
KW  - Swelling
KW  - Enzymatic degradation
KW  - In-vivo evaluation
UR  - https://www.sciencedirect.com/science/article/pii/S014486171930829X
L2  - https://www.sciencedirect.com/science/article/pii/S014486171930829X
N2  - Hyaluronan (HA) films exhibit properties suitable for medical applications, but the solubility of HA limits their use in aqueous environments. This can be overcome by modifying HA with hydrophobic side groups that enable physical cross-linking. In this work, we present water insoluble free-standing films from lauroyl modified HA as novel biomaterials with properties tuneable by the degree of HA substitution. The films are homogeneous, mechanically strong, and flexible and can be sterilized by ethylenoxide. To characterize the films, we measured their thickness, dry mass, content of residual organic solvent, mechanical properties, swelling and enzymatic degradation. The safety and biodegradability of the films were tested both in-vitro and in-vivo, showing that the films are safe and that their degradation can be tailored by the degree of HA substitution.
ER  -

CHMELAR, J.; J. MRAZEK; M. HERMANNOVA; L. KUBALA; G. AMBROZOVA; Anna KOCURKOVÁ; T. DRMOTA; K. NESPOROVA; L. GRUSOVA a V. VELEBNY. Biodegradable free-standing films from lauroyl derivatives of hyaluronan. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2019, roč.~224, NOV 15 2019, s.~1-7. ISSN~0144-8617. Dostupné z: https://doi.org/10.1016/j.carbpol.2019.115162.

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