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@article{1643079,
author = {Martínková, Natália and Škrabánek, Pavel and Pikula, Jiří},
article_location = {London},
article_number = {March 2019},
doi = {http://dx.doi.org/10.1016/j.jtbi.2018.12.026},
keywords = {Pathogen load; Skin lesion; Fungal infection; Pseudogymnoascus destructans; White-nose syndrome; Bat; UV light diagnostics},
language = {eng},
issn = {0022-5193},
journal = {Journal of Theoretical Biology},
title = {Modelling invasive pathogen load from non-destructive sampling data},
url = {http://dx.doi.org/10.1016/j.jtbi.2018.12.026},
volume = {464},
year = {2019}
}
TY - JOUR
ID - 1643079
AU - Martínková, Natália - Škrabánek, Pavel - Pikula, Jiří
PY - 2019
TI - Modelling invasive pathogen load from non-destructive sampling data
JF - Journal of Theoretical Biology
VL - 464
IS - March 2019
SP - 98-103
EP - 98-103
PB - Elsevier
SN - 00225193
KW - Pathogen load
KW - Skin lesion
KW - Fungal infection
KW - Pseudogymnoascus destructans
KW - White-nose syndrome
KW - Bat
KW - UV light diagnostics
UR - http://dx.doi.org/10.1016/j.jtbi.2018.12.026
L2 - http://dx.doi.org/10.1016/j.jtbi.2018.12.026
N2 - Where microbes colonizing skin surface may help maintain organism homeostasis, those that invade living skin layers cause disease. In bats, white-nose syndrome is a fungal skin infection that affects animals during hibernation and may lead to mortality in severe cases. Here, we inferred the amount of fungus that had invaded skin tissue of diseased animals. We used simulations to estimate the unobserved disease severity in a non-lethal wing punch biopsy and to relate the simulated pathology to the measured fungal load in paired biopsies. We found that a single white-nose syndrome skin lesion packed with spores and hyphae of the causative agent, Pseudogymnoascus destructans, contains 48.93 pg of the pathogen DNA, which amounts to about 1560 P destructans genomes in one skin lesion.
ER -
MARTÍNKOVÁ, Natália, Pavel ŠKRABÁNEK a Jiří PIKULA. Modelling invasive pathogen load from non-destructive sampling data. \textit{Journal of Theoretical Biology}. London: Elsevier, 2019, roč.~464, March 2019, s.~98-103. ISSN~0022-5193. Dostupné z: https://dx.doi.org/10.1016/j.jtbi.2018.12.026.
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