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@article{1643319,
author = {Doležalová, Irena and Kunst, Jonáš and Kojan, Martin and Chrastina, Jan and Baláž, Marek and Brázdil, Milan},
article_location = {Netherlands},
article_number = {2019},
doi = {http://dx.doi.org/10.1016/j.ebr.2019.100344},
keywords = {Case report; Deep brain stimulation of the anterior nucleus of the thalamus},
language = {eng},
issn = {2589-9864},
journal = {Epilepsy and Behavior Reports},
title = {Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation},
url = {https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub},
volume = {12},
year = {2019}
}
TY - JOUR
ID - 1643319
AU - Doležalová, Irena - Kunst, Jonáš - Kojan, Martin - Chrastina, Jan - Baláž, Marek - Brázdil, Milan
PY - 2019
TI - Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation
JF - Epilepsy and Behavior Reports
VL - 12
IS - 2019
SP - 1-3
EP - 1-3
PB - Elsevier BV
SN - 25899864
KW - Case report
KW - Deep brain stimulation of the anterior nucleus of the thalamus
UR - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
N2 - We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.
ER -
DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ a Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. \textit{Epilepsy and Behavior Reports}. Netherlands: Elsevier BV, 2019, roč.~12, č.~2019, s.~1-3. ISSN~2589-9864. Dostupné z: https://dx.doi.org/10.1016/j.ebr.2019.100344.
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