New 1 3 5-triazine Derivatives Incorporating
Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or
Stilbene Structural Motifs and Evaluation of Their
Antioxidative Activity	 (PDF) New 1,3,5-triazine Derivatives
Incorporating Aminobenzenesulfonamide, Aminoalcohol,
Piperazine, Chalcone or Stilbene Structural Motifs and
Evaluation of Their Antioxidative Activity. Available from:
https://www.researchgate.net/publication/337285387_New_135-tria
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ohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Eval
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New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_135-triazine_Derivatives_Incorporating_Aminobenzenesulfonamide_Aminoalcohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Evaluation_of_Their_Antiox

HAVRÁNKOVÁ, Eva; Nikola ČALKOVSKÁ; Tereza PADRTOVÁ; Jozef CSÖLLEI; Radka OPATŘILOVÁ et al.

Základní údaje

Originální název

New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_135-triazine_Derivatives_Incorporating_Aminobenzenesulfonamide_Aminoalcohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Evaluation_of_Their_Antiox

Autoři

HAVRÁNKOVÁ, Eva ; Nikola ČALKOVSKÁ; Tereza PADRTOVÁ; Jozef CSÖLLEI; Radka OPATŘILOVÁ a Pavel PAZDERA

Vydání

The 23rd International Electronic Conference on Synthetic Organic Chemistry, 2019

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10401 Organic chemistry

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.3390/ecsoc-23-06598

Klíčová slova anglicky

1 3 5-triazine; 4-aminophenol; hydroxychalcone; hydroxystilbene; antioxidative activity; ABTS method

Změněno: 23. 2. 2021 12:20, Mgr. Hana Hurtová

Anotace

V originále

A series of 1,3,5-triazine derivatives, incorporating aminobenzenesulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step by step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and IC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest used concentration 1 × 10-4 M, the %inhibition activity at time 0 min was comparable with both standards at least for 10 compounds. After 60 min compounds 1, 2, 9 and 25 showed nearly twice %inhibition (73.44–87.09%) in comparison with standards (Trolox = 41.49%; ASA = 31.07%). Values of IC50 correlated with %inhibition activity. For compounds 1, 2, 9 and 25 values of IC50 in time 60 min (17.16–27.78 μM) were 5 times lower than IC50 of both standards (Trolox = 178.33 μM; ASA = 147.47 μM). Based on these results, the presented 1,3,5-triazine derivatives and their analogs have a high potential in the treatment of illnesses caused or related to oxidative stress.

Citovat

HAVRÁNKOVÁ, Eva; Nikola ČALKOVSKÁ; Tereza PADRTOVÁ; Jozef CSÖLLEI; Radka OPATŘILOVÁ a Pavel PAZDERA. New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_135-triazine_Derivatives_Incorporating_Aminobenzenesulfonamide_Aminoalcohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Evaluation_of_Their_Antiox. In The 23rd International Electronic Conference on Synthetic Organic Chemistry. 2019. Dostupné z: https://doi.org/10.3390/ecsoc-23-06598.

@proceedings{1649378,
   author = {Havránková, Eva and Čalkovská, Nikola and Padrtová, Tereza and Csöllei, Jozef and Opatřilová, Radka and Pazdera, Pavel},
   booktitle = {The 23rd International Electronic Conference on Synthetic Organic Chemistry},
   doi = {https://doi.org/10.3390/ecsoc-23-06598},
   keywords = {1 3 5-triazine; 4-aminophenol; hydroxychalcone; hydroxystilbene; antioxidative activity; ABTS method},
   language = {eng},
   title = {New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_135-triazine_Derivatives_Incorporating_Aminobenzenesulfonamide_Aminoalcohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Evaluation_of_Their_Antiox},
   url = {https://sciforum.net/paper/view/conference/6598},
   year = {2019}
}

TY  - CONF
ID  - 1649378
AU  - Havránková, Eva - Čalkovská, Nikola - Padrtová, Tereza - Csöllei, Jozef - Opatřilová, Radka - Pazdera, Pavel
PY  - 2019
TI  - New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387_New_135-triazine_Derivatives_Incorporating_Aminobenzenesulfonamide_Aminoalcohol_Piperazine_Chalcone_or_Stilbene_Structural_Motifs_and_Evaluation_of_Their_Antiox
KW  - 1 3 5-triazine
KW  - 4-aminophenol
KW  - hydroxychalcone
KW  - hydroxystilbene
KW  - antioxidative activity
KW  - ABTS method
UR  - https://sciforum.net/paper/view/conference/6598
L2  - https://sciforum.net/paper/view/conference/6598
N2  - A series of 1,3,5-triazine derivatives, incorporating aminobenzenesulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step by step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and IC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest used concentration 1 × 10-4 M, the %inhibition activity at time 0 min was comparable with both standards at least for 10 compounds. After 60 min compounds 1, 2, 9 and 25 showed nearly twice %inhibition (73.44–87.09%) in comparison with standards (Trolox = 41.49%; ASA = 31.07%). Values of IC50 correlated with %inhibition activity. For compounds 1, 2, 9 and 25 values of IC50 in time 60 min (17.16–27.78 μM) were 5 times lower than IC50 of both standards (Trolox = 178.33 μM; ASA = 147.47 μM). Based on these results, the presented 1,3,5-triazine derivatives and their analogs have a high potential in the treatment of illnesses caused or related to oxidative stress.
ER  -

HAVRÁNKOVÁ, Eva; Nikola ČALKOVSKÁ; Tereza PADRTOVÁ; Jozef CSÖLLEI; Radka OPATŘILOVÁ a Pavel PAZDERA. New 1 3 5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity (PDF) New 1,3,5-triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity. Available from: https://www.researchgate.net/publication/337285387\_{}New\_{}135-triazine\_{}Derivatives\_{}Incorporating\_{}Aminobenzenesulfonamide\_{}Aminoalcohol\_{}Piperazine\_{}Chalcone\_{}or\_{}Stilbene\_{}Structural\_{}Motifs\_{}and\_{}Evaluation\_{}of\_{}Their\_{}Antiox. In \textit{The 23rd International Electronic Conference on Synthetic Organic Chemistry}. 2019. Dostupné z: https://doi.org/10.3390/ecsoc-23-06598.

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