Další formáty:
BibTeX
LaTeX
RIS
@article{1650036, author = {Tsivgoulis, G. and Katsanos, A. H. and Sharma, V. K. and Krogias, C. and Mikulík, Robert and Vadikolias, K. and Mijajlovic, M. and Safouris, A. and Zompola, C. and Faissner, S. and Weiss, V. and Giannopoulos, S. and Vasdekis, S. and Boviatsis, E. and Alexandrov, A. W. and Voumvourakis, K. and Alexandrov, A. V.}, article_location = {Philadelphia}, article_number = {12}, doi = {http://dx.doi.org/10.1212/WNL.0000000000002493}, keywords = {ACUTE ISCHEMIC-STROKE; HEALTH-CARE PROFESSIONALS; CAROTID-ENDARTERECTOMY; INTRAVENOUS THROMBOLYSIS; EARLY MANAGEMENT; PILOT TRIAL; EARLY RISK; MULTICENTER; ATTACK; RECURRENCE}, language = {eng}, issn = {0028-3878}, journal = {Neurology}, title = {Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke}, url = {http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4820133&blobtype=pdf}, volume = {86}, year = {2016} }
TY - JOUR ID - 1650036 AU - Tsivgoulis, G. - Katsanos, A. H. - Sharma, V. K. - Krogias, C. - Mikulík, Robert - Vadikolias, K. - Mijajlovic, M. - Safouris, A. - Zompola, C. - Faissner, S. - Weiss, V. - Giannopoulos, S. - Vasdekis, S. - Boviatsis, E. - Alexandrov, A. W. - Voumvourakis, K. - Alexandrov, A. V. PY - 2016 TI - Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke JF - Neurology VL - 86 IS - 12 SP - 1103-1111 EP - 1103-1111 PB - LIPPINCOTT WILLIAMS & WILKINS SN - 00283878 KW - ACUTE ISCHEMIC-STROKE KW - HEALTH-CARE PROFESSIONALS KW - CAROTID-ENDARTERECTOMY KW - INTRAVENOUS THROMBOLYSIS KW - EARLY MANAGEMENT KW - PILOT TRIAL KW - EARLY RISK KW - MULTICENTER KW - ATTACK KW - RECURRENCE UR - http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4820133&blobtype=pdf L2 - http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4820133&blobtype=pdf N2 - Objective: Even though statin pretreatment is associated with better functional outcomes and lower risk of mortality in acute ischemic stroke, there are limited data evaluating this association in acute ischemic stroke due to large artery atherosclerosis (LAA), which carries the highest risk of early stroke recurrence. Methods: Consecutive patients with acute LAA were prospectively evaluated from 7 tertiary-care stroke centers during a 3-year period. Statin pretreatment, demographics, vascular risk factors, and admission and discharge stroke severity were recorded. The outcome events of interest were neurologic improvement during hospitalization (quantified as the relative decrease in NIH Stroke Scale score at discharge in comparison to hospital admission), favorable functional outcome (FFO) (defined as modified Rankin Scale score of 0-1), recurrent stroke, and death at 1 month. Statistical analyses were performed using univariable and multivariable Cox regression models adjusting for potential confounders. All analyses were repeated following propensity score matching. Results: Statin pretreatment was documented in 192 (37.2%) of 516 consecutive patients with LAA (mean age: 65 +/- 13 years; 60.8% men; median NIH Stroke Scale score: 9 points, interquartile range: 5-18). Statin pretreatment was associated with greater neurologic improvement during hospitalization and higher rates of 30-day FFO in unmatched and matched (odds ratio for FFO: 2.44; 95% confidence interval [CI]: 1.07-5.53) analyses. It was also related to lower risk of 1-month mortality and stroke recurrence in unmatched and matched analyses (hazard ratio for recurrent stroke: 0.11, 95% CI: 0.02-0.46; hazard ratio for death: 0.24, 95% CI: 0.08-0.75). Conclusion: Statin pretreatment in patients with acute LAA appears to be associated with better early outcomes regarding neurologic improvement, disability, survival, and stroke recurrence. ER -
TSIVGOULIS, G., A. H. KATSANOS, V. K. SHARMA, C. KROGIAS, Robert MIKULÍK, K. VADIKOLIAS, M. MIJAJLOVIC, A. SAFOURIS, C. ZOMPOLA, S. FAISSNER, V. WEISS, S. GIANNOPOULOS, S. VASDEKIS, E. BOVIATSIS, A. W. ALEXANDROV, K. VOUMVOURAKIS a A. V. ALEXANDROV. Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke. \textit{Neurology}. Philadelphia: LIPPINCOTT WILLIAMS \&{} WILKINS, 2016, roč.~86, č.~12, s.~1103-1111. ISSN~0028-3878. Dostupné z: https://dx.doi.org/10.1212/WNL.0000000000002493.
|