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@article{1650036,
author = {Tsivgoulis, G. and Katsanos, A. H. and Sharma, V. K. and Krogias, C. and Mikulík, Robert and Vadikolias, K. and Mijajlovic, M. and Safouris, A. and Zompola, C. and Faissner, S. and Weiss, V. and Giannopoulos, S. and Vasdekis, S. and Boviatsis, E. and Alexandrov, A. W. and Voumvourakis, K. and Alexandrov, A. V.},
article_location = {Philadelphia},
article_number = {12},
doi = {http://dx.doi.org/10.1212/WNL.0000000000002493},
keywords = {ACUTE ISCHEMIC-STROKE; HEALTH-CARE PROFESSIONALS; CAROTID-ENDARTERECTOMY; INTRAVENOUS THROMBOLYSIS; EARLY MANAGEMENT; PILOT TRIAL; EARLY RISK; MULTICENTER; ATTACK; RECURRENCE},
language = {eng},
issn = {0028-3878},
journal = {Neurology},
title = {Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke},
url = {http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4820133&blobtype=pdf},
volume = {86},
year = {2016}
}
TY - JOUR
ID - 1650036
AU - Tsivgoulis, G. - Katsanos, A. H. - Sharma, V. K. - Krogias, C. - Mikulík, Robert - Vadikolias, K. - Mijajlovic, M. - Safouris, A. - Zompola, C. - Faissner, S. - Weiss, V. - Giannopoulos, S. - Vasdekis, S. - Boviatsis, E. - Alexandrov, A. W. - Voumvourakis, K. - Alexandrov, A. V.
PY - 2016
TI - Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke
JF - Neurology
VL - 86
IS - 12
SP - 1103-1111
EP - 1103-1111
PB - LIPPINCOTT WILLIAMS & WILKINS
SN - 00283878
KW - ACUTE ISCHEMIC-STROKE
KW - HEALTH-CARE PROFESSIONALS
KW - CAROTID-ENDARTERECTOMY
KW - INTRAVENOUS THROMBOLYSIS
KW - EARLY MANAGEMENT
KW - PILOT TRIAL
KW - EARLY RISK
KW - MULTICENTER
KW - ATTACK
KW - RECURRENCE
UR - http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4820133&blobtype=pdf
L2 - http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4820133&blobtype=pdf
N2 - Objective: Even though statin pretreatment is associated with better functional outcomes and lower risk of mortality in acute ischemic stroke, there are limited data evaluating this association in acute ischemic stroke due to large artery atherosclerosis (LAA), which carries the highest risk of early stroke recurrence. Methods: Consecutive patients with acute LAA were prospectively evaluated from 7 tertiary-care stroke centers during a 3-year period. Statin pretreatment, demographics, vascular risk factors, and admission and discharge stroke severity were recorded. The outcome events of interest were neurologic improvement during hospitalization (quantified as the relative decrease in NIH Stroke Scale score at discharge in comparison to hospital admission), favorable functional outcome (FFO) (defined as modified Rankin Scale score of 0-1), recurrent stroke, and death at 1 month. Statistical analyses were performed using univariable and multivariable Cox regression models adjusting for potential confounders. All analyses were repeated following propensity score matching. Results: Statin pretreatment was documented in 192 (37.2%) of 516 consecutive patients with LAA (mean age: 65 +/- 13 years; 60.8% men; median NIH Stroke Scale score: 9 points, interquartile range: 5-18). Statin pretreatment was associated with greater neurologic improvement during hospitalization and higher rates of 30-day FFO in unmatched and matched (odds ratio for FFO: 2.44; 95% confidence interval [CI]: 1.07-5.53) analyses. It was also related to lower risk of 1-month mortality and stroke recurrence in unmatched and matched analyses (hazard ratio for recurrent stroke: 0.11, 95% CI: 0.02-0.46; hazard ratio for death: 0.24, 95% CI: 0.08-0.75). Conclusion: Statin pretreatment in patients with acute LAA appears to be associated with better early outcomes regarding neurologic improvement, disability, survival, and stroke recurrence.
ER -
TSIVGOULIS, G., A. H. KATSANOS, V. K. SHARMA, C. KROGIAS, Robert MIKULÍK, K. VADIKOLIAS, M. MIJAJLOVIC, A. SAFOURIS, C. ZOMPOLA, S. FAISSNER, V. WEISS, S. GIANNOPOULOS, S. VASDEKIS, E. BOVIATSIS, A. W. ALEXANDROV, K. VOUMVOURAKIS a A. V. ALEXANDROV. Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke. \textit{Neurology}. Philadelphia: LIPPINCOTT WILLIAMS \&{} WILKINS, 2016, roč.~86, č.~12, s.~1103-1111. ISSN~0028-3878. Dostupné z: https://dx.doi.org/10.1212/WNL.0000000000002493.
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