| LEHTO, Lauri J., Antonietta CANNA, Lin WU, Alejandra SIERRA, Ekaterina ZHURAKOVSKAYA, Jun MA, Clairice PEARCE, Maple SHAIO, Pavel FILIP, Matthew D. JOHNSON, Walter C. LOW, Olli GROHN, Heikki TANILA, Silvia MANGIA a Shalom MICHAELI. Orientation selective deep brain stimulation of the subthalamic nucleus in rats. Neuroimage. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, roč. 213, JUN 2020, s. 1-10. ISSN 1053-8119. Dostupné z: https://dx.doi.org/10.1016/j.neuroimage.2020.116750. |
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@article{1650577,
author = {Lehto, Lauri J. and Canna, Antonietta and Wu, Lin and Sierra, Alejandra and Zhurakovskaya, Ekaterina and Ma, Jun and Pearce, Clairice and Shaio, Maple and Filip, Pavel and Johnson, Matthew D. and Low, Walter C. and Grohn, Olli and Tanila, Heikki and Mangia, Silvia and Michaeli, Shalom},
article_location = {SAN DIEGO},
article_number = {JUN 2020},
doi = {http://dx.doi.org/10.1016/j.neuroimage.2020.116750},
keywords = {Deep brain stimulation; Subthalamic nucleus; fMRI; Orientation selective; Parkinson's disease; Movement disorders},
language = {eng},
issn = {1053-8119},
journal = {Neuroimage},
title = {Orientation selective deep brain stimulation of the subthalamic nucleus in rats},
url = {https://www.sciencedirect.com/science/article/pii/S1053811920302378?via%3Dihub},
volume = {213},
year = {2020}
}
TY - JOUR
ID - 1650577
AU - Lehto, Lauri J. - Canna, Antonietta - Wu, Lin - Sierra, Alejandra - Zhurakovskaya, Ekaterina - Ma, Jun - Pearce, Clairice - Shaio, Maple - Filip, Pavel - Johnson, Matthew D. - Low, Walter C. - Grohn, Olli - Tanila, Heikki - Mangia, Silvia - Michaeli, Shalom
PY - 2020
TI - Orientation selective deep brain stimulation of the subthalamic nucleus in rats
JF - Neuroimage
VL - 213
IS - JUN 2020
SP - 1-10
EP - 1-10
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 10538119
KW - Deep brain stimulation
KW - Subthalamic nucleus
KW - fMRI
KW - Orientation selective
KW - Parkinson's disease
KW - Movement disorders
UR - https://www.sciencedirect.com/science/article/pii/S1053811920302378?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1053811920302378?via%3Dihub
N2 - Deep brain stimulation (DBS) has become an important tool in the management of a wide spectrum of diseases in neurology and psychiatry. Target selection is a vital aspect of DBS so that only the desired areas are stimulated. Segmented leads and current steering have been shown to be promising additions to DBS technology enabling better control of the stimulating electric field. Recently introduced orientation selective DBS (OS-DBS) is a related development permitting sensitization of the stimulus to axonal pathways with different orientations by freely controlling the primary direction of the electric field using multiple contacts. Here, we used OS-DBS to stimulate the subthalamic nucleus (STN) in healthy rats while simultaneously monitoring the induced brain activity with fMRI. Maximal activation of the sensorimotor and basal ganglia-thalamocortical networks was observed when the electric field was aligned mediolaterally in the STN pointing in the lateral direction, while no cortical activation was observed with the electric field pointing medially to the opposite direction. Such findings are consistent with mediolateral main direction of the STN fibers, as seen with high resolution diffusion imaging and histology. The asymmetry of the OS-DBS dipolar field distribution using three contacts along with the potential stimulation of the internal capsule, are also discussed. We conclude that OS-DBS offers an additional degree of flexibility for optimization of DBS of the STN which may enable a better treatment response.
ER -
LEHTO, Lauri J., Antonietta CANNA, Lin WU, Alejandra SIERRA, Ekaterina ZHURAKOVSKAYA, Jun MA, Clairice PEARCE, Maple SHAIO, Pavel FILIP, Matthew D. JOHNSON, Walter C. LOW, Olli GROHN, Heikki TANILA, Silvia MANGIA a Shalom MICHAELI. Orientation selective deep brain stimulation of the subthalamic nucleus in rats. \textit{Neuroimage}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, roč.~213, JUN 2020, s.~1-10. ISSN~1053-8119. Dostupné z: https://dx.doi.org/10.1016/j.neuroimage.2020.116750.
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