Simplified Procedure for General Synthesis of Monosubstituted
Piperazines—From a Batch Reaction Vessel to a Flow (Microwave)
Reactor

J 2020

Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor

NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK, Pavel PAZDERA et. al.

Základní údaje

Originální název

Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor

Autoři

NĚMEČKOVÁ, Dana (203 Česká republika, domácí), Eva HAVRÁNKOVÁ (203 Česká republika, domácí), Jan ŠIMBERA (203 Česká republika, domácí), Richard ŠEVČÍK (203 Česká republika, garant, domácí) a Pavel PAZDERA (203 Česká republika, domácí)

Vydání

Molecules, Basel, MDPI, 2020, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.411

Kód RIV

RIV/00216224:14310/20:00114840

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/molecules25092168

UT WoS

000535695900164

Klíčová slova anglicky

piperazine; monosubstituted; derivative; heterocyclic; catalysis; heterogeneous; microwave; synthesis; supported catalyst; reactor

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 11. 2020 13:21, Mgr. Marie Šípková, DiS.

Anotace

V originále

We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.

Návaznosti

MUNI/31/53569/2016, interní kód MU

Název: Průtokový reaktor s mikrovlnným zdrojem a/nebo katalytickým ložem – konstrukce a SWOT analýza jeho použití (Akronym: MW reaktor)

Investor: Masarykova univerzita, Průtokový reaktor s mikrovlnným zdrojem a/nebo katalytickým ložem – konstrukce a SWOT analýza jeho použití

TG02010067, projekt VaV

Název: Rozvoj systému komercializace výsledků VaV na Masarykově univerzitě (Akronym: Rozvoj systému komercializace na MU)

Investor: Technologická agentura ČR, Rozvoj systému komercializace výsledků VaV na Masarykově univerzitě II., Podprogram 1

Citovat

NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK a Pavel PAZDERA. Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor. Molecules. Basel: MDPI, 2020, roč. 25, č. 9, s. 1-15. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules25092168.

@article{1652656,
   author = {Němečková, Dana and Havránková, Eva and Šimbera, Jan and Ševčík, Richard and Pazdera, Pavel},
   article_location = {Basel},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/molecules25092168},
   keywords = {piperazine; monosubstituted; derivative; heterocyclic; catalysis; heterogeneous; microwave; synthesis; supported catalyst; reactor},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor},
   url = {https://doi.org/10.3390/molecules25092168},
   volume = {25},
   year = {2020}
}

TY  - JOUR
ID  - 1652656
AU  - Němečková, Dana - Havránková, Eva - Šimbera, Jan - Ševčík, Richard - Pazdera, Pavel
PY  - 2020
TI  - Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor
JF  - Molecules
VL  - 25
IS  - 9
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 14203049
KW  - piperazine
KW  - monosubstituted
KW  - derivative
KW  - heterocyclic
KW  - catalysis
KW  - heterogeneous
KW  - microwave
KW  - synthesis
KW  - supported catalyst
KW  - reactor
UR  - https://doi.org/10.3390/molecules25092168
L2  - https://doi.org/10.3390/molecules25092168
N2  - We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.
ER  -

NĚMEČKOVÁ, Dana, Eva HAVRÁNKOVÁ, Jan ŠIMBERA, Richard ŠEVČÍK a Pavel PAZDERA. Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor. \textit{Molecules}. Basel: MDPI, 2020, roč.~25, č.~9, s.~1-15. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules25092168.

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