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@article{1668822,
author = {Doležel, Zdeněk and Ješina, Pavel and Stiburkova, Blanka},
article_location = {New York},
article_number = {8},
doi = {http://dx.doi.org/10.1007/s00467-020-04493-8},
keywords = {severe hyperuricemia; acute gastroenteritis; children},
language = {eng},
issn = {0931-041X},
journal = {Pediatric Nephrology},
title = {Severe hyperuricemia in two children with acute gastroenteritis: answers},
url = {https://link.springer.com/article/10.1007/s00467-020-04493-8},
volume = {35},
year = {2020}
}
TY - JOUR
ID - 1668822
AU - Doležel, Zdeněk - Ješina, Pavel - Stiburkova, Blanka
PY - 2020
TI - Severe hyperuricemia in two children with acute gastroenteritis: answers
JF - Pediatric Nephrology
VL - 35
IS - 8
SP - 1431-1435
EP - 1431-1435
PB - Springer
SN - 0931041X
KW - severe hyperuricemia
KW - acute gastroenteritis
KW - children
UR - https://link.springer.com/article/10.1007/s00467-020-04493-8
L2 - https://link.springer.com/article/10.1007/s00467-020-04493-8
N2 - Uric acid (UA) is the end product of purine catabolism in humanoids, since the hepatocyte enzyme uricase, which degrades UA to allantoin in other mammals, is completely inactive. Approximately 65–75% of the UA produced daily is excreted by the kidneys, while the remaining 25–35% exits in the stool. Homeostasis of UA is determined by the balance between production and excretion. Hyperuricemia is caused by all conditions associated with increased purine synthesis and degradation during excessive cell breakdown and follow-up catabolism of nucleic acids, or an inability of the kidneys and gastrointestinal tract relative to urate excretion and clearance. During childhood, it is important to evaluate age- and sex-related serum UA concentration with respect to reference values.
ER -
DOLEŽEL, Zdeněk, Pavel JEŠINA a Blanka STIBURKOVA. Severe hyperuricemia in two children with acute gastroenteritis: answers. \textit{Pediatric Nephrology}. New York: Springer, 2020, roč.~35, č.~8, s.~1431-1435. ISSN~0931-041X. Dostupné z: https://dx.doi.org/10.1007/s00467-020-04493-8.
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