The potential actions of angiotensin-converting enzyme II
(ACE2) activator diminazene aceturate (DIZE) in various
diseases

J 2020

The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases

QARADAKHI, T., L. K. GADANEC, K. R. MCSWEENEY, A. TACEY, V. APOSTOLOPOULOS et. al.

Základní údaje

Originální název

The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases

Autoři

QARADAKHI, T. (36 Austrálie), L. K. GADANEC (36 Austrálie), K. R. MCSWEENEY (36 Austrálie), A. TACEY (36 Austrálie), V. APOSTOLOPOULOS (36 Austrálie), I. LEVINGER (36 Austrálie), K. RIMAROVA (703 Slovensko), E. E. EGOM (124 Kanada), L. RODRIGO (724 Španělsko), Peter KRUŽLIAK (703 Slovensko, garant, domácí), P. KUBATKA (703 Slovensko) a A. ZULLI (36 Austrálie)

Vydání

Clinical and Experimental Pharmacology and Physiology, Australia, Blackwell Publishing Australia, 2020, 0305-1870

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.557

Kód RIV

RIV/00216224:14110/20:00115986

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/1440-1681.13251

UT WoS

000509618900001

Klíčová slova anglicky

angiotensin-converting enzyme II; cardiovascular disease; diminazene aceturate; endothelial dysfunction; renin angiotensin system

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 7. 2020 10:04, Mgr. Tereza Miškechová

Anotace

V originále

The renin angiotensin system (RAS) regulates fluid balance, blood pressure and maintains vascular tone. The potent vasoconstrictor angiotensin II (Ang II) produced by angiotensin-converting enzyme (ACE) comprises the classical RAS. The non-classical RAS involves the conversion of Ang II via ACE2 into the vasodilator Ang (1-7) to counterbalance the effects of Ang II. Furthermore, ACE2 converts AngA into another vasodilator named alamandine. The over activation of the classical RAS (increased vasoconstriction) and depletion of the non-classical RAS (decreased vasodilation) results in vascular dysfunction. Vascular dysfunction is the leading cause of atherosclerosis and cardiovascular disease (CVD). Additionally, local RAS is expressed in various tissues and regulates cellular functions. RAS dysregulation is involved in other several diseases such as inflammation, renal dysfunction and even cancer growth. An approach in restoring vascular dysfunction and other pathological diseases is to either increase the activity of ACE2 or reduce the effect of the classical RAS by counterbalancing Ang II effects. The antitrypanosomal agent, diminazene aceturate (DIZE), is one approach in activating ACE2. DIZE has been shown to exert beneficial effects in CVD experimental models of hypertension, myocardial infarction, type 1 diabetes and atherosclerosis. Thus, this review focuses on DIZE and its effect in several tissues such as blood vessels, cardiac, renal, immune and cancer cells.

Citovat

QARADAKHI, T., L. K. GADANEC, K. R. MCSWEENEY, A. TACEY, V. APOSTOLOPOULOS, I. LEVINGER, K. RIMAROVA, E. E. EGOM, L. RODRIGO, Peter KRUŽLIAK, P. KUBATKA a A. ZULLI. The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases. Clinical and Experimental Pharmacology and Physiology. Australia: Blackwell Publishing Australia, 2020, roč. 47, č. 5, s. 751-758. ISSN 0305-1870. Dostupné z: https://dx.doi.org/10.1111/1440-1681.13251.

@article{1670356,
   author = {Qaradakhi, T. and Gadanec, L. K. and McSweeney, K. R. and Tacey, A. and Apostolopoulos, V. and Levinger, I. and Rimarova, K. and Egom, E. E. and Rodrigo, L. and Kružliak, Peter and Kubatka, P. and Zulli, A.},
   article_location = {Australia},
   article_number = {5},
   doi = {http://dx.doi.org/10.1111/1440-1681.13251},
   keywords = {angiotensin-converting enzyme II; cardiovascular disease; diminazene aceturate; endothelial dysfunction; renin angiotensin system},
   language = {eng},
   issn = {0305-1870},
   journal = {Clinical and Experimental Pharmacology and Physiology},
   title = {The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13251},
   volume = {47},
   year = {2020}
}

TY  - JOUR
ID  - 1670356
AU  - Qaradakhi, T. - Gadanec, L. K. - McSweeney, K. R. - Tacey, A. - Apostolopoulos, V. - Levinger, I. - Rimarova, K. - Egom, E. E. - Rodrigo, L. - Kružliak, Peter - Kubatka, P. - Zulli, A.
PY  - 2020
TI  - The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases
JF  - Clinical and Experimental Pharmacology and Physiology
VL  - 47
IS  - 5
SP  - 751-758
EP  - 751-758
PB  - Blackwell Publishing Australia
SN  - 03051870
KW  - angiotensin-converting enzyme II
KW  - cardiovascular disease
KW  - diminazene aceturate
KW  - endothelial dysfunction
KW  - renin angiotensin system
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13251
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13251
N2  - The renin angiotensin system (RAS) regulates fluid balance, blood pressure and maintains vascular tone. The potent vasoconstrictor angiotensin II (Ang II) produced by angiotensin-converting enzyme (ACE) comprises the classical RAS. The non-classical RAS involves the conversion of Ang II via ACE2 into the vasodilator Ang (1-7) to counterbalance the effects of Ang II. Furthermore, ACE2 converts AngA into another vasodilator named alamandine. The over activation of the classical RAS (increased vasoconstriction) and depletion of the non-classical RAS (decreased vasodilation) results in vascular dysfunction. Vascular dysfunction is the leading cause of atherosclerosis and cardiovascular disease (CVD). Additionally, local RAS is expressed in various tissues and regulates cellular functions. RAS dysregulation is involved in other several diseases such as inflammation, renal dysfunction and even cancer growth. An approach in restoring vascular dysfunction and other pathological diseases is to either increase the activity of ACE2 or reduce the effect of the classical RAS by counterbalancing Ang II effects. The antitrypanosomal agent, diminazene aceturate (DIZE), is one approach in activating ACE2. DIZE has been shown to exert beneficial effects in CVD experimental models of hypertension, myocardial infarction, type 1 diabetes and atherosclerosis. Thus, this review focuses on DIZE and its effect in several tissues such as blood vessels, cardiac, renal, immune and cancer cells.
ER  -

QARADAKHI, T., L. K. GADANEC, K. R. MCSWEENEY, A. TACEY, V. APOSTOLOPOULOS, I. LEVINGER, K. RIMAROVA, E. E. EGOM, L. RODRIGO, Peter KRUŽLIAK, P. KUBATKA a A. ZULLI. The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases. \textit{Clinical and Experimental Pharmacology and Physiology}. Australia: Blackwell Publishing Australia, 2020, roč.~47, č.~5, s.~751-758. ISSN~0305-1870. Dostupné z: https://dx.doi.org/10.1111/1440-1681.13251.

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