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@article{1670596,
author = {Motiejunaite, J. and Akiyama, E. and CohenandSolal, A. and Maggioni, A. P. and Mueller, C. and Choi, D. J. and Kavoliuniene, A. and Celutkiene, J. and Pařenica, Jiří and Lassus, J. and Kajimoto, K. and Sato, N. and Miro, O. and Peacock, W. F. and Matsue, Y. and Voors, A. A. and Lam, C. S. P. and Ezekowitz, J. A. and Ahmed, A. and Fonarow, G. C. and Gayat, E. and RegitzandZagrosek, V. and Mebazaa, A.},
article_location = {Oxford},
article_number = {13},
doi = {http://dx.doi.org/10.1093/eurheartj/ehaa071},
keywords = {Acute heart failure; Gender; Biological sex; Mortality; Prognosis},
language = {eng},
issn = {0195-668X},
journal = {European heart journal},
title = {The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions},
url = {https://watermark.silverchair.com/ehaa071.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs0wggLJBgkqhkiG9w0BBwagggK6MIICtgIBADCCAq8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMt6G9vzj7d05TE7lwAgEQgIICgKpdeCE-BOO_5Vlg9onFq07m_ofMivuOkzQg1HJg9rwdgz},
volume = {41},
year = {2020}
}
TY - JOUR
ID - 1670596
AU - Motiejunaite, J. - Akiyama, E. - Cohen-Solal, A. - Maggioni, A. P. - Mueller, C. - Choi, D. J. - Kavoliuniene, A. - Celutkiene, J. - Pařenica, Jiří - Lassus, J. - Kajimoto, K. - Sato, N. - Miro, O. - Peacock, W. F. - Matsue, Y. - Voors, A. A. - Lam, C. S. P. - Ezekowitz, J. A. - Ahmed, A. - Fonarow, G. C. - Gayat, E. - Regitz-Zagrosek, V. - Mebazaa, A.
PY - 2020
TI - The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions
JF - European heart journal
VL - 41
IS - 13
SP - 1357-1364
EP - 1357-1364
PB - Oxford University Press
SN - 0195668X
KW - Acute heart failure
KW - Gender
KW - Biological sex
KW - Mortality
KW - Prognosis
UR - https://watermark.silverchair.com/ehaa071.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs0wggLJBgkqhkiG9w0BBwagggK6MIICtgIBADCCAq8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMt6G9vzj7d05TE7lwAgEQgIICgKpdeCE-BOO_5Vlg9onFq07m_ofMivuOkzQg1HJg9rwdgz
L2 - https://watermark.silverchair.com/ehaa071.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs0wggLJBgkqhkiG9w0BBwagggK6MIICtgIBADCCAq8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMt6G9vzj7d05TE7lwAgEQgIICgKpdeCE-BOO_5Vlg9onFq07m_ofMivuOkzQg1HJg9rwdgz
N2 - Aims Recent data from national registries suggest that acute heart failure (AHF) outcomes might vary in men and women, however, it is not known whether this observation is universal. The aim of this study was to evaluate the association of biological sex and 1-year all-cause mortality in patients with AHF in various regions of the world. Methods and Results We analysed several AHF cohorts including GREAT registry (22 523 patients, mostly from Europe and Asia) and OPTIMIZE-HF (26 376 patients from the USA). Clinical characteristics and medication use at discharge were collected. Hazard ratios (HRs) for 1-year mortality according to biological sex were calculated using a Cox proportional hazards regression model with adjustment for baseline characteristics (e.g. age, comorbidities, clinical and laboratory parameters at admission, Left ventricular ejection fraction). In the GREAT registry, women had a Lower risk of death in the year following AHF [HR 0.86 (0.79-0.94), P< 0.001 after adjustment]. This was mostly driven by northeast Asia [n=9135, HR 0.76 (0.67-0.87), P< 0.001], while no significant differences were seen in other countries. In the OPTIMIZE-HF registry, women also had a tower risk of 1-year death [HR 0.93 (0.89-0.97), P < 0.001]. In the GREAT registry, women were less often prescribed with a combination of angiotensin-converting enzyme inhibitors and beta-Mockers at discharge (50% vs. 57%, P = 0.001). Conclusion Globally women with AHF have a lower 1-year mortality and less evidenced-based treatment than men. Differences among countries need further investigation. Our findings merit consideration when designing future global clinical trials in AHF.
ER -
MOTIEJUNAITE, J., E. AKIYAMA, A. COHEN-SOLAL, A. P. MAGGIONI, C. MUELLER, D. J. CHOI, A. KAVOLIUNIENE, J. CELUTKIENE, Jiří PAŘENICA, J. LASSUS, K. KAJIMOTO, N. SATO, O. MIRO, W. F. PEACOCK, Y. MATSUE, A. A. VOORS, C. S. P. LAM, J. A. EZEKOWITZ, A. AHMED, G. C. FONAROW, E. GAYAT, V. REGITZ-ZAGROSEK a A. MEBAZAA. The association of lorg-term outcome and biological sex in patients with acute heart failure from different geographic regions. \textit{European heart journal}. Oxford: Oxford University Press, 2020, roč.~41, č.~13, s.~1357-1364. ISSN~0195-668X. Dostupné z: https://dx.doi.org/10.1093/eurheartj/ehaa071.
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