Cold atmospheric pressure plasma: simple and efficient strategy
for preparation of poly(2-oxazoline)-based coatings designed
for biomedical applications

J 2020

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

ŠRÁMKOVÁ, Petra; Anna ZAHORANOVÁ; Jakub KELAR; Zlata KELAR TUČEKOVÁ; Monika STUPAVSKÁ et al.

Základní údaje

Originální název

Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications

Autoři

ŠRÁMKOVÁ, Petra; Anna ZAHORANOVÁ; Jakub KELAR; Zlata KELAR TUČEKOVÁ; Monika STUPAVSKÁ; Richard KRUMPOLEC ; Jana JURMANOVÁ; Dušan KOVÁČIK a Mirko ČERNÁK

Vydání

Scientific Reports, London, Nature Publishing Group, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10305 Fluids and plasma physics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.380

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/20:00116039

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

2-oxazolín; tenké vrstvy; studené plazma; DCSBD; bunková adheze, bioaplikace

Klíčová slova anglicky

2-oxazoline; thin layers; cold plasma; DCSBD; cell adhesion; bioapplications

Štítky

14312030, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 4. 2021 18:38, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POx-based copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of “cold” homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days.

Návaznosti

EF16_027/0008360, projekt VaV

Název: Postdoc@MUNI

90110, velká výzkumná infrastruktura

Název: CzechNanoLab

Citovat

ŠRÁMKOVÁ, Petra; Anna ZAHORANOVÁ; Jakub KELAR; Zlata KELAR TUČEKOVÁ; Monika STUPAVSKÁ; Richard KRUMPOLEC; Jana JURMANOVÁ; Dušan KOVÁČIK a Mirko ČERNÁK. Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications. Scientific Reports. London: Nature Publishing Group, 2020, roč. 10, č. 1, s. 1-13. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-020-66423-w.

@article{1671141,
   author = {Šrámková, Petra and Zahoranová, Anna and Kelar, Jakub and Kelar Tučeková, Zlata and Stupavská, Monika and Krumpolec, Richard and Jurmanová, Jana and Kováčik, Dušan and Černák, Mirko},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-020-66423-w},
   keywords = {2-oxazoline; thin layers; cold plasma; DCSBD; cell adhesion; bioapplications},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications},
   url = {https://www.nature.com/articles/s41598-020-66423-w},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1671141
AU  - Šrámková, Petra - Zahoranová, Anna - Kelar, Jakub - Kelar Tučeková, Zlata - Stupavská, Monika - Krumpolec, Richard - Jurmanová, Jana - Kováčik, Dušan - Černák, Mirko
PY  - 2020
TI  - Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-13
EP  - 1-13
PB  - Nature Publishing Group
SN  - 20452322
KW  - 2-oxazoline
KW  - thin layers
KW  - cold plasma
KW  - DCSBD
KW  - cell adhesion
KW  - bioapplications
UR  - https://www.nature.com/articles/s41598-020-66423-w
L2  - https://www.nature.com/articles/s41598-020-66423-w
N2  - Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POx-based copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of “cold” homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days.
ER  -

ŠRÁMKOVÁ, Petra; Anna ZAHORANOVÁ; Jakub KELAR; Zlata KELAR TUČEKOVÁ; Monika STUPAVSKÁ; Richard KRUMPOLEC; Jana JURMANOVÁ; Dušan KOVÁČIK a Mirko ČERNÁK. Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-13. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-020-66423-w.

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