Micrometastases in Sentinel Lymph Nodes Represent a Significant
Negative Prognostic Factor in Early-Stage Cervical Cancer: A
Single-Institutional Retrospective Cohort Study

J 2020

Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study

KOCIAN, Roman; Jiri SLAMA; Daniela FISCHEROVA; Anna GERMANOVA; Andrea BURGETOVA et al.

Základní údaje

Originální název

Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study

Autoři

Vydání

Cancers, BASEL, MDPI, 2020, 2072-6694

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.639

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00116113

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3390/cancers12061438

UT WoS

000549262500001

EID Scopus

2-s2.0-85085760636

Klíčová slova anglicky

micrometastasis; isolated tumor cells; sentinel lymph node; cervical cancer; pathological ultrastaging; prognostic parameters; risk of recurrence

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 8. 2020 13:42, Mgr. Tereza Miškechová

Anotace

V originále

The data on the prognostic significance of low volume metastases in lymph nodes (LN) are inconsistent. The aim of this study was to retrospectively analyze the outcome of a large group of patients treated with sentinel lymph node (SLN) biopsy at a single referral center. Patients with cervical cancer, stage T1a-T2b, common tumor types, negative LN on preoperative staging, treated by primary surgery between 01/2007 and 12/2016, with at least unilateral SLN detection were included. Patients with abandoned radical surgery due to intraoperative SLN positivity detected by frozen section were excluded. All SLNs were postoperatively processed by an intensive protocol for pathological ultrastaging. Altogether, 226 patients were analyzed. Positive LN were detected in 38 (17%) cases; macrometastases (MAC), micrometastases (MIC), isolated tumor cells (ITC) in 14, 16, and 8 patients. With the median follow-up of 65 months, 22 recurrences occurred. Disease-free survival (DFS) reached 90% in the whole group, 93% in LN-negative cases, 89% in cases with MAC, 69% with MIC, and 87% with ITC. The presence of MIC in SLN was associated with significantly decreased DFS and OS. Patients with MIC and MAC should be managed similarly, and SLN ultrastaging should become an integral part of the management of patients with early-stage cervical cancer.

Citovat

KOCIAN, Roman; Jiri SLAMA; Daniela FISCHEROVA; Anna GERMANOVA; Andrea BURGETOVA; Ladislav DUŠEK; Pavel DUNDR; Kristyna NEMEJCOVA; Jiří JARKOVSKÝ; Silvie SEBESTOVA; Filip FRUHAUF; Lukas DOSTALEK; Tereza BALLASCHOVA a David CIBULA. Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study. Cancers. BASEL: MDPI, 2020, roč. 12, č. 6, s. 1-14. ISSN 2072-6694. Dostupné z: https://doi.org/10.3390/cancers12061438.

@article{1672840,
   author = {Kocian, Roman and Slama, Jiri and Fischerova, Daniela and Germanova, Anna and Burgetova, Andrea and Dušek, Ladislav and Dundr, Pavel and Nemejcova, Kristyna and Jarkovský, Jiří and Sebestova, Silvie and Fruhauf, Filip and Dostalek, Lukas and Ballaschova, Tereza and Cibula, David},
   article_location = {BASEL},
   article_number = {6},
   doi = {https://doi.org/10.3390/cancers12061438},
   keywords = {micrometastasis; isolated tumor cells; sentinel lymph node; cervical cancer; pathological ultrastaging; prognostic parameters; risk of recurrence},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study},
   url = {https://www.mdpi.com/2072-6694/12/6/1438},
   volume = {12},
   year = {2020}
}

TY  - JOUR
ID  - 1672840
AU  - Kocian, Roman - Slama, Jiri - Fischerova, Daniela - Germanova, Anna - Burgetova, Andrea - Dušek, Ladislav - Dundr, Pavel - Nemejcova, Kristyna - Jarkovský, Jiří - Sebestova, Silvie - Fruhauf, Filip - Dostalek, Lukas - Ballaschova, Tereza - Cibula, David
PY  - 2020
TI  - Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study
JF  - Cancers
VL  - 12
IS  - 6
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 20726694
KW  - micrometastasis
KW  - isolated tumor cells
KW  - sentinel lymph node
KW  - cervical cancer
KW  - pathological ultrastaging
KW  - prognostic parameters
KW  - risk of recurrence
UR  - https://www.mdpi.com/2072-6694/12/6/1438
L2  - https://www.mdpi.com/2072-6694/12/6/1438
N2  - The data on the prognostic significance of low volume metastases in lymph nodes (LN) are inconsistent. The aim of this study was to retrospectively analyze the outcome of a large group of patients treated with sentinel lymph node (SLN) biopsy at a single referral center. Patients with cervical cancer, stage T1a-T2b, common tumor types, negative LN on preoperative staging, treated by primary surgery between 01/2007 and 12/2016, with at least unilateral SLN detection were included. Patients with abandoned radical surgery due to intraoperative SLN positivity detected by frozen section were excluded. All SLNs were postoperatively processed by an intensive protocol for pathological ultrastaging. Altogether, 226 patients were analyzed. Positive LN were detected in 38 (17%) cases; macrometastases (MAC), micrometastases (MIC), isolated tumor cells (ITC) in 14, 16, and 8 patients. With the median follow-up of 65 months, 22 recurrences occurred. Disease-free survival (DFS) reached 90% in the whole group, 93% in LN-negative cases, 89% in cases with MAC, 69% with MIC, and 87% with ITC. The presence of MIC in SLN was associated with significantly decreased DFS and OS. Patients with MIC and MAC should be managed similarly, and SLN ultrastaging should become an integral part of the management of patients with early-stage cervical cancer.
ER  -

KOCIAN, Roman; Jiri SLAMA; Daniela FISCHEROVA; Anna GERMANOVA; Andrea BURGETOVA; Ladislav DUŠEK; Pavel DUNDR; Kristyna NEMEJCOVA; Jiří JARKOVSKÝ; Silvie SEBESTOVA; Filip FRUHAUF; Lukas DOSTALEK; Tereza BALLASCHOVA a David CIBULA. Micrometastases in Sentinel Lymph Nodes Represent a Significant Negative Prognostic Factor in Early-Stage Cervical Cancer: A Single-Institutional Retrospective Cohort Study. \textit{Cancers}. BASEL: MDPI, 2020, roč.~12, č.~6, s.~1-14. ISSN~2072-6694. Dostupné z: https://doi.org/10.3390/cancers12061438.

Přehled o publikaci