The therapeutic effect of B-type natriuretic peptides in acute
decompensated heart failure

J 2020

The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure

CAPRNDA, Martin; Anthony ZULLI; Haaris A. SHIWANI; Peter KUBATKA; Slavomira FILIPOVA et al.

Základní údaje

Originální název

The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure

Autoři

Vydání

Clinical and Experimental Pharmacology and Physiology, Australia, Blackwell Publishing Australia, 2020, 0305-1870

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.557

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00116163

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

B-type natriuretic peptide; clinical effectiveness; heart failure; pharmacotherapy

Štítky

14110116, 14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 8. 2020 10:35, Mgr. Tereza Miškechová

Anotace

V originále

B-type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.

Citovat

CAPRNDA, Martin; Anthony ZULLI; Haaris A. SHIWANI; Peter KUBATKA; Slavomira FILIPOVA; Vanda VALENTOVA; Katarina GAZDIKOVA; Ioana MOZOS; Andrius BERUKSTIS; Aleksandras LAUCEVICIUS; Ivan ŘIHÁČEK; Jozef DRAGASEK; Robert PROSECKY; Emmanuel E. EGOM; Robert STAFFA; Peter KRUŽLIAK a Vladimir KRASNIK. The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure. Clinical and Experimental Pharmacology and Physiology. Australia: Blackwell Publishing Australia, 2020, roč. 47, č. 7, s. 1120-1133. ISSN 0305-1870. Dostupné z: https://doi.org/10.1111/1440-1681.13290.

@article{1673737,
   author = {Caprnda, Martin and Zulli, Anthony and Shiwani, Haaris A. and Kubatka, Peter and Filipova, Slavomira and Valentova, Vanda and Gazdikova, Katarina and Mozos, Ioana and Berukstis, Andrius and Laucevicius, Aleksandras and Řiháček, Ivan and Dragasek, Jozef and Prosecky, Robert and Egom, Emmanuel E. and Staffa, Robert and Kružliak, Peter and Krasnik, Vladimir},
   article_location = {Australia},
   article_number = {7},
   doi = {https://doi.org/10.1111/1440-1681.13290},
   keywords = {B-type natriuretic peptide; clinical effectiveness; heart failure; pharmacotherapy},
   language = {eng},
   issn = {0305-1870},
   journal = {Clinical and Experimental Pharmacology and Physiology},
   title = {The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290},
   volume = {47},
   year = {2020}
}

TY  - JOUR
ID  - 1673737
AU  - Caprnda, Martin - Zulli, Anthony - Shiwani, Haaris A. - Kubatka, Peter - Filipova, Slavomira - Valentova, Vanda - Gazdikova, Katarina - Mozos, Ioana - Berukstis, Andrius - Laucevicius, Aleksandras - Řiháček, Ivan - Dragasek, Jozef - Prosecky, Robert - Egom, Emmanuel E. - Staffa, Robert - Kružliak, Peter - Krasnik, Vladimir
PY  - 2020
TI  - The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure
JF  - Clinical and Experimental Pharmacology and Physiology
VL  - 47
IS  - 7
SP  - 1120-1133
EP  - 1120-1133
PB  - Blackwell Publishing Australia
SN  - 03051870
KW  - B-type natriuretic peptide
KW  - clinical effectiveness
KW  - heart failure
KW  - pharmacotherapy
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290
N2  - B-type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.
ER  -

CAPRNDA, Martin; Anthony ZULLI; Haaris A. SHIWANI; Peter KUBATKA; Slavomira FILIPOVA; Vanda VALENTOVA; Katarina GAZDIKOVA; Ioana MOZOS; Andrius BERUKSTIS; Aleksandras LAUCEVICIUS; Ivan ŘIHÁČEK; Jozef DRAGASEK; Robert PROSECKY; Emmanuel E. EGOM; Robert STAFFA; Peter KRUŽLIAK a Vladimir KRASNIK. The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure. \textit{Clinical and Experimental Pharmacology and Physiology}. Australia: Blackwell Publishing Australia, 2020, roč.~47, č.~7, s.~1120-1133. ISSN~0305-1870. Dostupné z: https://doi.org/10.1111/1440-1681.13290.

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