Primary Mammary Organoid Model of Lactation and Involution

J 2020

Primary Mammary Organoid Model of Lactation and Involution

SUMBAL, Jakub; Aurelie CHICHE; Elsa CHARIFOU; Zuzana KOLEDOVÁ; Han LI et. al.

Základní údaje

Originální název

Primary Mammary Organoid Model of Lactation and Involution

Autoři

SUMBAL, Jakub; Aurelie CHICHE; Elsa CHARIFOU; Zuzana KOLEDOVÁ a Han LI

Vydání

Frontiers in Cell and Developmental Biology, Lausanne, Frontiers Media S.A. 2020, 2296-634X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.684

Kód RIV

RIV/00216224:14110/20:00116164

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3389/fcell.2020.00068

UT WoS

000525631100001

EID Scopus

2-s2.0-85086156648

Klíčová slova anglicky

3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin

Štítky

14110517, CF CELLIM, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 5. 2025 13:01, Mgr. Tereza Miškechová

Anotace

V originále

Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.

Návaznosti

MUNI/A/1382/2019, interní kód MU

Název: Zdroje pro tkáňové inženýrství 10 (Akronym: TissueEng 10)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 10, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1565/2018, interní kód MU

Název: Zdroje pro tkáňové inženýrství 9 (Akronym: TissueEng 9)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 9, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/G/1446/2018, interní kód MU

Název: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masarykova univerzita, Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling, INTERDISCIPLINARY - Mezioborové výzkumné projekty

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

Citovat

SUMBAL, Jakub; Aurelie CHICHE; Elsa CHARIFOU; Zuzana KOLEDOVÁ a Han LI. Primary Mammary Organoid Model of Lactation and Involution. Frontiers in Cell and Developmental Biology. Lausanne: Frontiers Media S.A., 2020, roč. 8, MAR 2020, s. 1-13. ISSN 2296-634X. Dostupné z: https://doi.org/10.3389/fcell.2020.00068.

@article{1673739,
   author = {Sumbal, Jakub and Chiche, Aurelie and Charifou, Elsa and Koledová, Zuzana and Li, Han},
   article_location = {Lausanne},
   article_number = {MAR 2020},
   doi = {https://doi.org/10.3389/fcell.2020.00068},
   keywords = {3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {Primary Mammary Organoid Model of Lactation and Involution},
   url = {https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full},
   volume = {8},
   year = {2020}
}

TY  - JOUR
ID  - 1673739
AU  - Sumbal, Jakub - Chiche, Aurelie - Charifou, Elsa - Koledová, Zuzana - Li, Han
PY  - 2020
TI  - Primary Mammary Organoid Model of Lactation and Involution
JF  - Frontiers in Cell and Developmental Biology
VL  - 8
IS  - MAR 2020
SP  - 1-13
EP  - 1-13
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - 3D culture
KW  - fibroblast growth factor 2
KW  - involution
KW  - lactation
KW  - mammary gland
KW  - milk production
KW  - organoid
KW  - prolactin
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
L2  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
N2  - Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
ER  -

SUMBAL, Jakub; Aurelie CHICHE; Elsa CHARIFOU; Zuzana KOLEDOVÁ a Han LI. Primary Mammary Organoid Model of Lactation and Involution. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2020, roč.~8, MAR 2020, s.~1-13. ISSN~2296-634X. Dostupné z: https://doi.org/10.3389/fcell.2020.00068.

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