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@article{1674636, author = {Rybárová, Natália and Pinková, Blanka and Došková, Hana and Vlková, Eva}, article_location = {Zagreb}, article_number = {1}, keywords = {ichthyosis; corneal perforation; ectropion; penetrating keratoplasty}, language = {eng}, issn = {1330-027X}, journal = {Acta Dermatovenerologica Croatica}, title = {Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report}, url = {https://pubmed.ncbi.nlm.nih.gov/32650848/}, volume = {28}, year = {2020} }
TY - JOUR ID - 1674636 AU - Rybárová, Natália - Pinková, Blanka - Došková, Hana - Vlková, Eva PY - 2020 TI - Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report JF - Acta Dermatovenerologica Croatica VL - 28 IS - 1 SP - 29-33 EP - 29-33 PB - Croatian Dermatovenerological Society SN - 1330027X KW - ichthyosis KW - corneal perforation KW - ectropion KW - penetrating keratoplasty UR - https://pubmed.ncbi.nlm.nih.gov/32650848/ L2 - https://pubmed.ncbi.nlm.nih.gov/32650848/ N2 - We report a case of lamellar ichthyosis and sight-threatening complications of cicatricial ectropion in an adult male patient which was sur- gically managed with tectonic penetrating keratoplasty. We present a case of autosomal-recessive lamellar ichthyosis in a 47-year-old man who was re- ferred to our outpatient eye clinic for treatment of primary keratouveitis of the right eye with keratolysis and exudation in the anterior chamber. A di- agnosis of cicatricial ectropion with serious lagophthalmos was established on examination. The patient underwent tectonic penetrating keratoplasty, cataract extraction, and intra-ocular lens placement with no perioperative complications. The patient was subsequently treated with oral fluconazole 200 mg once daily for 12 days due to a positive fungal culture for Candida albicans and systemic oral acyclovir 250 mg 3 times per day for 12 days as pro- phylaxis for a labial herpetic infection. Post-operative complications included corneal rejection and nonhealing neurotropic epithelial defect of the graft. Long-term treatment with topical cyclosporine (Ikervis®) and dexametha- sone led to resolution of the corneal rejection. Lubrication with artificial tears containing hyaluronic acid, perfluorohexyl octane (Evotears®), and vitamin A ointment led to symptomatic relief of dry eye disease. The patient was re- ferred to a dermatologist and was started on systemic retinoid acitretin at a dose of 0.5 mg/kg per day. Ten months after surgery, the patient’s visual acuity was 0.1 based on the Snellen chart and the corneal graft was stable. Infection in the cornea can rapidly progress to corneal melting in patients with severe cicatricial ectropion. A good patient outcome depends on the interdisciplinary approach to patient management by the ophthalmologist, dermatologist, and plastic surgeon. ER -
RYBÁROVÁ, Natália, Blanka PINKOVÁ, Hana DOŠKOVÁ a Eva VLKOVÁ. Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report. \textit{Acta Dermatovenerologica Croatica}. Zagreb: Croatian Dermatovenerological Society, 2020, roč.~28, č.~1, s.~29-33. ISSN~1330-027X.
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